{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Leonardi M"],"funding":["Regione Toscana"],"pagination":["312-326"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6333447"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(2)"],"pubmed_abstract":["Macroautophagy/autophagy is one of the major responses to stress in eukaryotic cells and is implicated in several pathological conditions such as infections, neurodegenerative diseases and cancer. Interestingly, cancer cells take full advantage of autophagy both to support tumor growth in adverse microenvironments and to oppose damages induced by anti-neoplastic therapies. Importantly, different human oncogenes are able to modulate this survival mechanism to support the transformation process, ultimately leading to 'autophagy addiction'. Still, oncogenic signaling events, impinging on the control of autophagy, are poorly characterized, limiting our possibilities to take advantage of these mechanisms for therapeutic purposes. Here, we screened a library of activated kinases for their abilit"],"journal":["Autophagy"],"pubmed_title":["Activated kinase screening identifies the <i>IKBKE</i> oncogene as a positive regulator of autophagy."],"pmcid":["PMC6333447"],"funding_grant_id":["ITT grant"],"pubmed_authors":["Perna E","Leonardi M","Colecchia D","Tronnolone S","Chiariello M"],"additional_accession":[]},"is_claimable":false,"name":"Activated kinase screening identifies the <i>IKBKE</i> oncogene as a positive regulator of autophagy.","description":"Macroautophagy/autophagy is one of the major responses to stress in eukaryotic cells and is implicated in several pathological conditions such as infections, neurodegenerative diseases and cancer. Interestingly, cancer cells take full advantage of autophagy both to support tumor growth in adverse microenvironments and to oppose damages induced by anti-neoplastic therapies. Importantly, different human oncogenes are able to modulate this survival mechanism to support the transformation process, ultimately leading to 'autophagy addiction'. Still, oncogenic signaling events, impinging on the control of autophagy, are poorly characterized, limiting our possibilities to take advantage of these mechanisms for therapeutic purposes. Here, we screened a library of activated kinases for their abilit","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2026-07-09T12:06:38.95Z","creation":"2026-07-09T11:08:50.092Z"},"accession":"S-EPMC6333447","cross_references":{"pubmed":["30289335"],"doi":["10.1080/15548627.2018.1517855"]}}