{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma F"],"funding":["National Natural Science Foundation of China"],"pagination":["1975"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6334161"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["The Althaea rosea (Linn.) flower is a common plant that is often used to control inflammation in Uyghur ethnic medicine. However, its active ingredients remain uncertain and difficult to identify, severely limiting its use as a valuable crop. This paper aims to establish a rapid assay strategy for the integration of ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS/MS) and a biologically active (NF-κB inhibitor) luciferase reporter detection system to explore various anti-inflammatory compounds of A. rosea (Linn.) flowers. Potential anti-inflammatory components were screened using the NF-κB activity assay system and simultaneously identified based on mass spectrometry data. Four structural types of NF-κB inhibitors (phenolic acid, hydroxycin"],"journal":["Frontiers in plant science"],"pubmed_title":["Combining UPLC/Q-TOF-MS/MS With Biological Evaluation for NF-κB Inhibitors in Uyghur Medicine Althaea rosea Flowers."],"pmcid":["PMC6334161"],"funding_grant_id":["81503214"],"pubmed_authors":["Ma F","Cui Q","Bai G"],"additional_accession":[]},"is_claimable":false,"name":"Combining UPLC/Q-TOF-MS/MS With Biological Evaluation for NF-κB Inhibitors in Uyghur Medicine Althaea rosea Flowers.","description":"The Althaea rosea (Linn.) flower is a common plant that is often used to control inflammation in Uyghur ethnic medicine. However, its active ingredients remain uncertain and difficult to identify, severely limiting its use as a valuable crop. This paper aims to establish a rapid assay strategy for the integration of ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS/MS) and a biologically active (NF-κB inhibitor) luciferase reporter detection system to explore various anti-inflammatory compounds of A. rosea (Linn.) flowers. Potential anti-inflammatory components were screened using the NF-κB activity assay system and simultaneously identified based on mass spectrometry data. Four structural types of NF-κB inhibitors (phenolic acid, hydroxycin","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-05-18T11:30:24.221Z","creation":"2025-05-18T11:30:24.221Z"},"accession":"S-EPMC6334161","cross_references":{"pubmed":["30687369"],"doi":["10.3389/fpls.2018.01975"]}}