biostudies-literatureAndresini OSapienza Università di Roma8https://www.ebi.ac.uk/biostudies/studies/S-EPMC6334472biostudies-literatureUnknown12(1)<h4>Background</h4>The cell-cycle inhibitor p57^kip2 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types. p57^kip2 expression is finely regulated by several epigenetic mechanisms, including paternal imprinting. Kcnq1ot1, a long non-coding RNA (LncRNA), whose gene maps to the p57^Kip2 imprinting domain, is expressed exclusively from the paternal allele and participates in the cis-silencing of the neighboring imprinted genes through chromatin-level regulation. In light of our previous evidence of a functional interaction between myogenic factors and imprinting control elements in the regulation of the maternal p57^Kip2 allele during muscle differentiation, we examined the possibility Epigenetics & chromatinThe long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region.PMC6334472RM11715C642DFF3BRP116154C9BD387BMaione RRossi MNAndresini OPetrai SSantini TMatteini FfalseThe long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region.<h4>Background</h4>The cell-cycle inhibitor p57^kip2 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types. p57^kip2 expression is finely regulated by several epigenetic mechanisms, including paternal imprinting. Kcnq1ot1, a long non-coding RNA (LncRNA), whose gene maps to the p57^Kip2 imprinting domain, is expressed exclusively from the paternal allele and participates in the cis-silencing of the neighboring imprinted genes through chromatin-level regulation. In light of our previous evidence of a functional interaction between myogenic factors and imprinting control elements in the regulation of the maternal p57^Kip2 allele during muscle differentiation, we examined the possibility 2019-01-01T00:00:00Z2019 Jan2026-07-16T16:25:27.462Z2025-05-18T11:32:13.403ZS-EPMC63344723065114010.1186/s13072-019-0253-1