biostudies-literatureUnknown47(2)van Haren FWellcome Trust<h4>Objectives</h4>To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to investigate whether the effects of spontaneous breathing on outcome depend on acute respiratory distress syndrome severity.<h4>Design</h4>Planned secondary analysis of a prospective, observational, multicentre cohort study.<h4>Setting</h4>International sample of 459 ICUs from 50 countries.<h4>Patients</h4>Patients with acute respiratory distress syndrome and at least 2 days of invasive mechanical ventilation and available data for the mode of mechanical ventilation and respiratory rate for the 2 first days.<h4>Interventions</h4>Analysis of patients with and without spontaneous breathing, defined by the mode of mechanical ventilatiCritical care medicine229-238https://www.ebi.ac.uk/biostudies/studies/S-EPMC6336491biostudies-literatureSpontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study.PMC6336491Foti GCurto EGPillai SMeybohm PLaffey JGHraiech SMontini LMLovazzano PLing LLRhayakar RVWatanabe EMacFie CCSimonis FDAker MSchioler FDi Tomasso NNTreanor NHurtado JDolva MSNoremark KALAlbarrak MMBhowmick KCardonnet LPScafetti SBulpa PASantos CBajwa EAndruszkiewicz PVercueil ATrinidad OAAl Jabbary ASRoche-Campo FVillar VYu RAmir FDangers LHacking DJShenoy AEstrella CRRuiz SRMukkera SRRiss KCMaca JKakar VBorello SAYu WYu TNamih MAbroug FAlmekhlaf GAisiku ICerny VPalaniswamy VFossali TNishikawa ECereijo EUchiyama ADeclercq PMPapavasilopoulou TGLombardo AGonzalez DRAzevedo LCLopez-Delgado JCGarcia PHSchuetz MZender HORicome SNunomiya SOurailogloy VMckechnie SEstilita JMKrstevski AOldroyd MGWelters IDHaddad YSchouten JAJha RRArabi YMBoyd OUnal NChiche JDStigler WChen KKennedy BCombes AVirgilio CGBauer PRPittini GSchlichting ABSantoli FLJaafar RFAbe TDeicas ACasement JLeemann-Refondini CNasu MBiondi RSCracchiolo ANMancebo JPota VMojoli FZogheib EHCirone RBanner-Goodspeed VMBlanco JMacfadyen RAllue RMSellors GPHedlund LLoiacono FACoppadoro ASchiavoni LCasalena PHigashijima UJakubowska KTiribelli NDunne ESRodgers HJShen JCastro SPecci EMataloun SDector DMNin NJassal Mde Prost NToth-Tarsoly PAlvarez AMGosselin RJInsaurralde CSBeloncle FVascotto ERGrissom CKZhu WHNagy EOJaveed ABisso MCVermassen JSetten MGHeidari FVargas MPZacharowsk KDMolin AWong HSRamirez Cervantes MMercat AOikonomou MANunes SLHan YMirabella LQin SHVillagomez ABeitler JRSchneider FThomas MNegoita SIEllis HEJochmans SGomaa DPiras CBarratt-Due ATabhan EUppalapati ALohner RBouchoucha SBraschi AKong JPersson LPhan NTRaaijmakers MOliveira BSHan HNewby LDean MNPoblano MAguirre JSMejia FJFEsteve FPatroniti NZein SOBailey MBMckenna TETodeschini MBiehler JJarquin-Badiola YDRuiz-Aguilar ALDaviaud FTan BCBriquet ASerra IMTwohey LSoreide EAl Dorzi HMQin THBalkhi HBesset SLTainter CTakada TMichel PSauvadet EPOcchipinti GPasanting-Lim RABBihari SFarias PADe Pablo RDoyen DDixit SBAguilar RZMatsumoto SAneman AVeljovic MBurtin PSchiavone VKadaba VShah BZani GBailey IMGhazi MSoler JALorente MDCIlaria Pattarino PTStephenson LGonzalez MMcCalman KHNygren IGoncalves CHIbanez-Santacruz MMahto HLSagar SVWilliams KEIrvine DAPalo JESanchez-Medina JRBadie JCSher SSchafer SHopf HFBreen DMAndoh KWang HXElisabet GMHe ZCitalan JECeniceros-Barros AAlonso JGSotillo Diaz JCJSolis-Quesada JECarteaux GAvila LEChoudry SBeduneau GMemon MVolta CACesar PSFan ECortez CAGraziani RRobine AZhao XYTallet Alfonso AALi BDonnelly AHerbrecht JEOgino YRanieri MCollins DVScott CJYuste LJSrinivasa LHonda HAu SMDavies KGArabi YHelleberg JLaake JHAlbaiceta GMLanspa MJPara LHFollin AArizmendi AHashida TQiu HVinzio MAmor MTakagi SVega LDKraßler JCanestrini SMuthuchellappan RMaghrabi KABruns MMO'Muircheartaigh ACHunt AWatt PMehta SBolon SDreyer KRAzad RHagan SJGomes RMDawson HMay MMLi QIchikado KBotteri MGianinetto HLi WLi XLi YIoannou NEugenio Luis PSDive AMDaubin CLeon Yoshido HHBaronia AKPellicer AMPiquilloud LLora PJiang LIzawa MLemus JSChristiansen AWessbergh JMatamis DArnal JMNutt CSamkaoui NGao YNAliaga FANavarro GMaeyama HNDemirkiran ONielsen JCollyer TCareless JPFierro JMSilesky Jimenez JIGordo FRoberts BLNiimi DDempsey GAjetunmobi OOHormis APImperio MCFranco NThompson BTPereira CSNunci LBiscione RRSanchez-Hurtado LANobrega DLorente JACastro AGLuo XForteza CZhang FRaj ASBeegle SHMorin AKAlbiero DFloris LMagret MPronovost AGritsan AIChau SKBrown SMPoli MMThompson MMClaverias LKajtor ILi QJBeck OZheng RBeck EParotto MDector DSmith MJTibblin AOMcleod AAlda RSKheir FSeethala RMillar RTLamb KDKheir FMWilliams AJVillagomez AJO'Kane SCShiozaki KHopkins PMonteiro JMAntonelli MMFartoukh MZhou SGattinoni LRecio NNWillett ELDe Gordoa LOXin-Hua QWang SHBatra HReske AWVitale MNAmin PWenham TSzakmany TKnoll JBroman LMLaffey JAlejandro RVWu YQMckee RMcAuley DFCamsooksai JNunez ESanchez-Ballesteros JGillis SSurbatovic MTemprano SBaboi LSun RChelly JRinia MSchultz MJPreez PDZhu BHUmbrello MRoux DRigaud JPYeatts DJJurado MTRichecoeur JRRamesh VJKannan SGIsmail MGazenkampf AADelsing AKameyama YIsmail DKnowles SImma VPDwyer RIglesias Moles SGoligher ECVillamagua BGBaltus TKurahashi KRodriguez RTinnirello AKalkoff MVasquez DNSim MReuter DErbabacan EBezzi MGOlga MFDe Cima-Iglesias SMoock MZacharas GAKumar AChabanne RSaito SCranshaw JHLi XLSaito KBlack CSKitch BTHuerta FPHumphreys SKPozzi MAndersen FHGoldgran-Toledano DRobles JBBaron RMLe Moal CTabhan EEFutami SBrizuela MRamirez-Alfaro CMColombo RStrauch UXu YBrito VASavioli MSanchez RMLiu JLGrelon FSaez AAAntonio ACPMontero LABarros FMMcarthur CElmasri MBumbasirevic VCerrato VIStaudinger TMorton AFrigyik ADRamirez-Gutierrez ABedreag OHBen Souissi AMesar TLebbinck HMohr NMKusumoto KClaraco-Vega LMNassar APGoodson JCDowling ATGomez-Flores SSOetting TWToribio DPAbad RDReynolds CKoyama KHonrubia TKamoun SBarros NCDupont HKiourtzieva EVCarbayo-Gorriz CHarrois AKulkarni SLora FSIotti GASanchez RJSottiaux TNakamura TPesenti AFerguson NDChouchene ILiu JLiu LRugonfalvi SFrati EBarberet GAguirre-Bermeo HJibaja MSaenz MGBugedo GEriksson KEBrazzi LEzzouine HMcNamee LNamendys-Silva SABuzancais GGirgin NKLi YYBramall JBouw MJElatrous SEstenssoro ECheng MPGrigoriev EGomez PESeasman CMiller RRFernandez ROMohammadreza Hashemian STulaimat ATomescu DRWhitehead CIlutovich SBerghe CSchomer AMartinho AMCooper RStamou EEArtigas AManoharan VHua MXAllan RMPham TAlisasis AUHeunks LPg Hj Ismail DMABSales VMOwens RLSlutsky ASRoser TPKimura HGrijalba CQDemoule AMustafa GMBoukhazna MMortaza SNeal JRaimondi FOsman EMPalmese SDanin PEMarum SMBurtenshaw AJAscoli APelletier NMontes Oscanoa FAThibault SMassa EVLiew KYDempaire GWoods PWPerez CPAn YCoxo CMSeven AGonzalez-Salamanca AStewart RDaldin JRampinelli AMGiarratano AVan Wezel HMKhebbeb SAltaf WDendane TDres MTerzi NLlinares Moya DDBrochard LZeggwagh AALarsson NOrtiz CAMarin MCO'Neill OWise MPGlietsch RCazorla-Barranquero FGSula HHanlon GCLemiale VElkhayari MZhang XYHessell RJYao QDellamonica JMontanha GMLarsson AYe ZLGao YProtti AMeersseman PSable SDRubenfeld GRosa JILlano MReschreiter HHuang QQJimenez AGHashemian SMAlexander PZhai ZBigot CShimizu KCarpentier DCombaux DMYumha JSCrouch DRNichol AGurjar MAdams JCBhardwaj VKGrubissich NWittebole XSmith OChapman RCurley GMiller JJGueret RMHolzgraefe BWarren JSalas JEHang AYDellera CDerman SSPapurica MRios FTarantino FCsabi PHou PCHuang XBAlgaba AFernandes ADVMouloudi EKCatorze NTZhou FCSklienka PRodriguez LLLynch JMRossi AFerguson ALynch JRafael SIMarcos DPGriffin ROHutton PJPiacentini EAMochizuki KRamakrishnan NBrunettini BWrathall DWHuff NGKashiwa YNavarra LPapanikolaou MNAppelberg HBerkelmans FBlakeman TCZhao JBuensuseso JAOzcelik MZhao HBeuret PAisa TMAoki NRaponi FFrendl GKamel GSilesky JCimic NGonzalez Rojas MASalahuddin NYamaji YBruhn ARRanero JLMattei AMeco BCO'Croinin DTapponnier RBettini LRUeno KMizuguchi IJovanovic BHeunks LMVenti AClarkson KTanaka HHou SKGelee BMonti GOkuda NAdamsson ROParhar KCortegiani ASeoane-Quiroga LSabelnikovs OHutchison RAArtiga MJDPintado MCCinnella GPenuelas OAdolfsson AEsteban ABumbasierevic VCohen JEFernandez AMSuzuki HUnnikrishnan RBeraldo DOKander TKnapman KMMessika JBenslama ARialp GAlvarez JVerstraete RHadfield DChena APalma DMGuttormsen ABCorneci DENavalpotro MABUeda TGoubaux BPlotnikow GABattle CEClarkson KPCeylan IPanarello GTakaba Avan Haren FCeunen HRittayamai NGjedsted JLosada EPFontenele DCKol MRKedelv HMcAuley DJog SADuranteau JHermosa CDiaz-Rodriguez EImai HDe Haro CDepuydt PHarasawa TCrapelli GFusari MHenderson GNitta KBrowne TSLarge observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) InvestigatorsShao HCani AShindhe SCrova PJQin JZazu ALopez EBLee JWrigge HMessias AMSjobo BAAraujo AMMartinez FTLabarca EFTang RRyosuke SLi-Xin ZRylander CCGanesan DShinn JOBorotto EEMarcu ABuise MPMarin JSivashanmugavel MPellegrini CACarreno NGKalaitzis EQin BSimon PLu WGeorge FGJudy CLu YWang CHirata APozo NCDi YDDepuyd PSpadaro SIto FPerez MPZantua KSWang WMaazouzi WInskip DMSerra CTrinder TJGally JGonzalez RMBellani GHeines SJGuerin CJamaati HFawkes DAPapazian LOss PYamaguchi OAkyol OOFormenti PMeaney EASandesc DOuanes ICole JMPrieto-Gonzalez MMellis CGomez PRAfalseSpontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study.<h4>Objectives</h4>To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to investigate whether the effects of spontaneous breathing on outcome depend on acute respiratory distress syndrome severity.<h4>Design</h4>Planned secondary analysis of a prospective, observational, multicentre cohort study.<h4>Setting</h4>International sample of 459 ICUs from 50 countries.<h4>Patients</h4>Patients with acute respiratory distress syndrome and at least 2 days of invasive mechanical ventilation and available data for the mode of mechanical ventilation and respiratory rate for the 2 first days.<h4>Interventions</h4>Analysis of patients with and without spontaneous breathing, defined by the mode of mechanical ventilati2019-01-01T00:00:00Z2019 Feb2026-07-16T17:46:28.875Z2026-07-09T11:10:04.407ZS-EPMC63364913037966810.1097/CCM.0000000000003519