{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Gross E"],"funding":["Freie Akademische Gesellschaft Basel","University of Basel","Swiss Headache Society","Swiss National Science Foundation","University of Basel Children&apos;s Hospital","University of Basel Hospital"],"pubmed_abstract":["<h4>Background</h4>Currently available prophylactic migraine treatment options are limited and are associated with many, often intolerable, side-effects. Various lines of research suggest that abnormalities in energy metabolism are likely to be part of migraine pathophysiology. Previously, a ketogenic diet (KD) has been reported to lead to a drastic reduction in migraine frequency. An alternative method to a strict KD is inducing a mild nutritional ketosis (0.4-2 mmol/l) with exogenous ketogenic substances. The aim of this randomised, placebo-controlled, double-blind, crossover, single-centre trial is to demonstrate safety and superiority of beta-hydroxybutyrate (βHB) in mineral salt form over placebo in migraine prevention.<h4>Methods/design</h4>Forty-five episodic migraineurs (5-14 migra"],"journal":["Trials"],"pagination":["61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6337840"],"repository":["biostudies-literature"],"pubmed_title":["Efficacy and safety of exogenous ketone bodies for preventive treatment of migraine: A study protocol for a single-centred, randomised, placebo-controlled, double-blind crossover trial."],"pmcid":["PMC6337840"],"pubmed_authors":["Fischer D","Putananickal N","Schmidt S","Cichon S","Vogt DR","Orsini AL","Gross E","Sandor P"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy and safety of exogenous ketone bodies for preventive treatment of migraine: A study protocol for a single-centred, randomised, placebo-controlled, double-blind crossover trial.","description":"<h4>Background</h4>Currently available prophylactic migraine treatment options are limited and are associated with many, often intolerable, side-effects. Various lines of research suggest that abnormalities in energy metabolism are likely to be part of migraine pathophysiology. Previously, a ketogenic diet (KD) has been reported to lead to a drastic reduction in migraine frequency. An alternative method to a strict KD is inducing a mild nutritional ketosis (0.4-2 mmol/l) with exogenous ketogenic substances. The aim of this randomised, placebo-controlled, double-blind, crossover, single-centre trial is to demonstrate safety and superiority of beta-hydroxybutyrate (βHB) in mineral salt form over placebo in migraine prevention.<h4>Methods/design</h4>Forty-five episodic migraineurs (5-14 migra","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2026-05-05T06:38:17.284Z","creation":"2019-03-26T22:39:02Z"},"accession":"S-EPMC6337840","cross_references":{"pubmed":["30654835"],"doi":["10.1186/s13063-018-3120-7"]}}