{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Su J"],"funding":["grants from the Infective Diseases Prevention and Cure Project of National Ministry of Public Health of China"],"pagination":["44"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6339288"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["<h4>Background</h4>The mosquito Aedes albopictus is an important vector for dengue virus (DENV) transmission. The midgut is the first barrier to mosquito infection by DENV, and this barrier is a critical factor affecting the vector competence of the mosquito. However, the molecular mechanism of the interaction between midgut and virus is unknown.<h4>Results</h4>Six small libraries of Ae. albopictus midgut RNAs were constructed, three of which from mosquitoes that were infected with DENV-2 after feeding on infected blood, and another three that remained uninfected with DENV-2 after feeding on same batch of infected blood. A total of 46 differentially expressed miRNAs were identified of which 17 significant differentially expressed miRNAs were selected. Compared to microRNA expression profil"],"journal":["Parasites & vectors"],"pubmed_title":["Screening for differentially expressed miRNAs in Aedes albopictus (Diptera: Culicidae) exposed to DENV-2 and their effect on replication of DENV-2 in C6/36 cells."],"pmcid":["PMC6339288"],"funding_grant_id":["2012ZX10004219"],"pubmed_authors":["Li C","Wu Q","Guo X","Yan T","Liu Q","Wang G","Zhu X","Su J","Xing D","Zhao T"],"additional_accession":[]},"is_claimable":false,"name":"Screening for differentially expressed miRNAs in Aedes albopictus (Diptera: Culicidae) exposed to DENV-2 and their effect on replication of DENV-2 in C6/36 cells.","description":"<h4>Background</h4>The mosquito Aedes albopictus is an important vector for dengue virus (DENV) transmission. The midgut is the first barrier to mosquito infection by DENV, and this barrier is a critical factor affecting the vector competence of the mosquito. However, the molecular mechanism of the interaction between midgut and virus is unknown.<h4>Results</h4>Six small libraries of Ae. albopictus midgut RNAs were constructed, three of which from mosquitoes that were infected with DENV-2 after feeding on infected blood, and another three that remained uninfected with DENV-2 after feeding on same batch of infected blood. A total of 46 differentially expressed miRNAs were identified of which 17 significant differentially expressed miRNAs were selected. Compared to microRNA expression profil","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2026-05-03T01:59:32.434Z","creation":"2025-05-29T21:46:38.982Z"},"accession":"S-EPMC6339288","cross_references":{"pubmed":["30658692"],"doi":["10.1186/s13071-018-3261-2"]}}