{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["You R"],"funding":["BLRD VA","Intramural NIH HHS","NCRR NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NHGRI NIH HHS","NCI NIH HHS","VA","NIH","Cancer Prevention and Research Institute of Texas","CSRD VA"],"pagination":["645-657"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6342490"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(6)"],"pubmed_abstract":["Somatic mutations can promote malignant transformation of airway epithelial cells and induce inflammatory responses directed against resultant tumors. Tumor-infiltrating T lymphocytes (TIL) in early-stage non-small cell lung cancer (NSCLC) secrete distinct proinflammatory cytokines, but the contribution of these TILs to tumor development and metastasis remains unknown. We show here that TILs in early-stage NSCLC are biased toward IL17A expression (Th17) when compared with adjacent tumor-free tissue, whereas Th17 cells are decreased in tumor infiltrating locoregional lymph nodes in advanced NSCLC. Mice in which <i>Pten</i> and <i>Smad4</i> (<i>Pts4<sup>d/d</sup></i> ) are deleted from airway epithelial cells develop spontaneous tumors, that share genetic signatures with squamous- (SQ.2b), a"],"journal":["Cancer immunology research"],"pubmed_title":["IL17A Regulates Tumor Latency and Metastasis in Lung Adeno and Squamous SQ.2b and AD.1 Cancer."],"pmcid":["PMC6342490"],"funding_grant_id":["BX002221","CA125123","AI036211, CA125123, and RR024574","R01HL117181-01","I01 CX000104","UM1HG006348","CX000104","R01 HL110883","P30 CA125123","RP120713","P30 AI036211","UM1 HG006348","ZIA ES103311","I01 BX002221","R01 HL117181","S10 RR024574","R01 AI125264"],"pubmed_authors":["Liu J","Perusich S","Lu W","Casal RF","Paust S","Cornwell L","You R","Burt BM","Creighton CJ","Hill-McAlester A","Kim M","Rosen D","Lazarus DR","Kheradmand F","Cho SN","Song LZ","Corry D","Tung HY","Yuan X","DeMayo FJ","Diehl G"],"additional_accession":[]},"is_claimable":false,"name":"IL17A Regulates Tumor Latency and Metastasis in Lung Adeno and Squamous SQ.2b and AD.1 Cancer.","description":"Somatic mutations can promote malignant transformation of airway epithelial cells and induce inflammatory responses directed against resultant tumors. Tumor-infiltrating T lymphocytes (TIL) in early-stage non-small cell lung cancer (NSCLC) secrete distinct proinflammatory cytokines, but the contribution of these TILs to tumor development and metastasis remains unknown. We show here that TILs in early-stage NSCLC are biased toward IL17A expression (Th17) when compared with adjacent tumor-free tissue, whereas Th17 cells are decreased in tumor infiltrating locoregional lymph nodes in advanced NSCLC. Mice in which <i>Pten</i> and <i>Smad4</i> (<i>Pts4<sup>d/d</sup></i> ) are deleted from airway epithelial cells develop spontaneous tumors, that share genetic signatures with squamous- (SQ.2b), a","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jun","modification":"2026-04-15T13:05:11.699Z","creation":"2019-03-26T22:39:12Z"},"accession":"S-EPMC6342490","cross_references":{"pubmed":["29653981"],"doi":["10.1158/2326-6066.cir-17-0554","10.1158/2326-6066.CIR-17-0554"]}}