{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["53(1)"],"submitter":["Cho H"],"pubmed_abstract":["<h4>Background</h4>The aim of this study was to investigate the clinical significance of Quilty lesions in endomyocardial biopsies (EMBs) of cardiac transplantation patients.<h4>Methods</h4>A total of 1190EMBs from 117 cardiac transplantation patients were evaluated histologically for Quilty lesions,acute cellular rejection, and antibody-mediated rejection. Cardiac allograft vasculopathy wasdiagnosed by computed tomography coronary angiography. Clinical information, including thepatients' survival was retrieved by a review of medical records.<h4>Results</h4>Eighty-eight patients(75.2%) were diagnosed with Quilty lesions, which were significantly associated with acute cellularrejection, but not with acute cellular rejection ≥ 2R or antibody-mediated rejection. In patientsdiagnosed with both Quilty lesions and acute cellular rejection, the time-to-onset of Quilty lesionsfrom transplantation was longer than that of acute cellular rejections. We found a significant associationbetween Quilty lesions and cardiac allograft vasculopathy. No significant relationship wasfound between Quilty lesions and the patients' survival.<h4>Conclusions</h4>Quilty lesion may be an indicator of previous acute cellular rejection rather than a predictor for future acute cellular rejection."],"journal":["Journal of pathology and translational medicine"],"pagination":["50-56"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6344801"],"repository":["biostudies-literature"],"pubmed_title":["Quilty Lesions in the Endomyocardial Biopsies after Heart Transplantation."],"pmcid":["PMC6344801"],"pubmed_authors":["Jeon ES","Cho H","Choi JO","Kim JS"],"additional_accession":[]},"is_claimable":false,"name":"Quilty Lesions in the Endomyocardial Biopsies after Heart Transplantation.","description":"<h4>Background</h4>The aim of this study was to investigate the clinical significance of Quilty lesions in endomyocardial biopsies (EMBs) of cardiac transplantation patients.<h4>Methods</h4>A total of 1190EMBs from 117 cardiac transplantation patients were evaluated histologically for Quilty lesions,acute cellular rejection, and antibody-mediated rejection. Cardiac allograft vasculopathy wasdiagnosed by computed tomography coronary angiography. Clinical information, including thepatients' survival was retrieved by a review of medical records.<h4>Results</h4>Eighty-eight patients(75.2%) were diagnosed with Quilty lesions, which were significantly associated with acute cellularrejection, but not with acute cellular rejection ≥ 2R or antibody-mediated rejection. In patientsdiagnosed with both Quilty lesions and acute cellular rejection, the time-to-onset of Quilty lesionsfrom transplantation was longer than that of acute cellular rejections. We found a significant associationbetween Quilty lesions and cardiac allograft vasculopathy. No significant relationship wasfound between Quilty lesions and the patients' survival.<h4>Conclusions</h4>Quilty lesion may be an indicator of previous acute cellular rejection rather than a predictor for future acute cellular rejection.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2025-04-25T23:28:27.576Z","creation":"2019-03-26T22:41:50Z"},"accession":"S-EPMC6344801","cross_references":{"pubmed":["30586951"],"doi":["10.4132/jptm.2018.11.30"]}}