biostudies-literatureUnknown53(1)Cho H<h4>Background</h4>The aim of this study was to investigate the clinical significance of Quilty lesions in endomyocardial biopsies (EMBs) of cardiac transplantation patients.<h4>Methods</h4>A total of 1190EMBs from 117 cardiac transplantation patients were evaluated histologically for Quilty lesions,acute cellular rejection, and antibody-mediated rejection. Cardiac allograft vasculopathy wasdiagnosed by computed tomography coronary angiography. Clinical information, including thepatients' survival was retrieved by a review of medical records.<h4>Results</h4>Eighty-eight patients(75.2%) were diagnosed with Quilty lesions, which were significantly associated with acute cellularrejection, but not with acute cellular rejection ≥ 2R or antibody-mediated rejection. In patientsdiagnosed with both Quilty lesions and acute cellular rejection, the time-to-onset of Quilty lesionsfrom transplantation was longer than that of acute cellular rejections. We found a significant associationbetween Quilty lesions and cardiac allograft vasculopathy. No significant relationship wasfound between Quilty lesions and the patients' survival.<h4>Conclusions</h4>Quilty lesion may be an indicator of previous acute cellular rejection rather than a predictor for future acute cellular rejection.Journal of pathology and translational medicine50-56https://www.ebi.ac.uk/biostudies/studies/S-EPMC6344801biostudies-literatureQuilty Lesions in the Endomyocardial Biopsies after Heart Transplantation.PMC6344801Jeon ESCho HChoi JOKim JSfalseQuilty Lesions in the Endomyocardial Biopsies after Heart Transplantation.<h4>Background</h4>The aim of this study was to investigate the clinical significance of Quilty lesions in endomyocardial biopsies (EMBs) of cardiac transplantation patients.<h4>Methods</h4>A total of 1190EMBs from 117 cardiac transplantation patients were evaluated histologically for Quilty lesions,acute cellular rejection, and antibody-mediated rejection. Cardiac allograft vasculopathy wasdiagnosed by computed tomography coronary angiography. Clinical information, including thepatients' survival was retrieved by a review of medical records.<h4>Results</h4>Eighty-eight patients(75.2%) were diagnosed with Quilty lesions, which were significantly associated with acute cellularrejection, but not with acute cellular rejection ≥ 2R or antibody-mediated rejection. In patientsdiagnosed with both Quilty lesions and acute cellular rejection, the time-to-onset of Quilty lesionsfrom transplantation was longer than that of acute cellular rejections. We found a significant associationbetween Quilty lesions and cardiac allograft vasculopathy. No significant relationship wasfound between Quilty lesions and the patients' survival.<h4>Conclusions</h4>Quilty lesion may be an indicator of previous acute cellular rejection rather than a predictor for future acute cellular rejection.2019-01-01T00:00:00Z2019 Jan2025-04-25T23:28:27.576Z2019-03-26T22:41:50ZS-EPMC63448013058695110.4132/jptm.2018.11.30