{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Westphal S"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6345037"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.<h4>Methods</h4>We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.<h4>Results</h4>A total of 547,644 genotyped markers were available for analysis. Following qua"],"journal":["BMC cardiovascular disorders"],"pubmed_title":["Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study."],"pmcid":["PMC6345037"],"funding_grant_id":["ME 3559/1-1"],"pubmed_authors":["Renner J","Alms A","Tittmann L","Meybohm P","Hachenberg T","Knuefermann P","Heinze H","Boehm O","Paxian M","Bein B","Hasenclever D","Mucha S","Goerlach G","Bauer M","Zacharowski K","Stevanovic A","Schilling T","Goetzenich A","Rossaint R","Moormann T","Werner C","Gruenewald M","Sander M","Wittmann M","Boening A","Meyer-Treschan T","Chalk K","Heringlake M","Kohlhaas M","Kuhr B","Kletzin F","Schwarzmann G","Stehr SN","Paarmann H","Strauchmann J","August K","Roesner J","Schoen J","Fichtlscherer AZS","Brosteanu O","Strouhal U","Albrecht M","Franke A","Sievers HH","Kienbaum P","Boening U","Morsbach KU","Westphal S","Treskatsch S","Mauff S","Fuernau G","Schaelte G","RIPHeart-Study Collaborators","Wiedenbeck C","Klotz S","Ferner M","Brandes IF","Felzen M","Winterhalter M","Degenhardt F","Smul T","Wolwender E","Laufenberg-Feldmann R","Reinhard K","Roewer N","Struck R","Hoeft A","Bergt S","Stoppe C","Weber C","Kortgen A","Coburn M","Reyher C","Wollbrueck M","Weigand M","Cremer J","Francksen H","Niemann B","Pense K","Baumgarten G","Iken S","Broch O","Scholz J"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study.","description":"<h4>Background</h4>The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.<h4>Methods</h4>We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.<h4>Results</h4>A total of 547,644 genotyped markers were available for analysis. Following qua","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2026-05-04T08:18:34.541Z","creation":"2019-03-26T22:43:48Z"},"accession":"S-EPMC6345037","cross_references":{"pubmed":["30678657"],"doi":["10.1186/s12872-019-1002-x"]}}