biostudies-literatureWestphal SDeutsche Forschungsgemeinschaft26https://www.ebi.ac.uk/biostudies/studies/S-EPMC6345037biostudies-literatureUnknown19(1)<h4>Background</h4>The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.<h4>Methods</h4>We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.<h4>Results</h4>A total of 547,644 genotyped markers were available for analysis. Following quaBMC cardiovascular disordersGenome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study.PMC6345037ME 3559/1-1Renner JAlms ATittmann LMeybohm PHachenberg TKnuefermann PHeinze HBoehm OPaxian MBein BHasenclever DMucha SGoerlach GBauer MZacharowski KStevanovic ASchilling TGoetzenich ARossaint RMoormann TWerner CGruenewald MSander MWittmann MBoening AMeyer-Treschan TChalk KHeringlake MKohlhaas MKuhr BKletzin FSchwarzmann GStehr SNPaarmann HStrauchmann JAugust KRoesner JSchoen JFichtlscherer AZSBrosteanu OStrouhal UAlbrecht MFranke ASievers HHKienbaum PBoening UMorsbach KUWestphal STreskatsch SMauff SFuernau GSchaelte GRIPHeart-Study CollaboratorsWiedenbeck CKlotz SFerner MBrandes IFFelzen MWinterhalter MDegenhardt FSmul TWolwender ELaufenberg-Feldmann RReinhard KRoewer NStruck RHoeft ABergt SStoppe CWeber CKortgen ACoburn MReyher CWollbrueck MWeigand MCremer JFrancksen HNiemann BPense KBaumgarten GIken SBroch OScholz JfalseGenome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study.<h4>Background</h4>The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.<h4>Methods</h4>We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.<h4>Results</h4>A total of 547,644 genotyped markers were available for analysis. Following qua2019-01-01T00:00:00Z2019 Jan2026-05-04T08:18:34.541Z2019-03-26T22:43:48ZS-EPMC63450373067865710.1186/s12872-019-1002-x