{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Asselman J"],"funding":["Vliz Philantropy Award","Fonds Wetenschappelijk Onderzoek"],"pagination":["675"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6345880"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Sea spray aerosols (SSAs) have profound effects on our climate and ecosystems. They also contain microbiota and biogenic molecules which could affect human health. Yet the exposure and effects of SSAs on human health remain poorly studied. Here, we exposed human lung cancer cells to extracts of a natural sea spray aerosol collected at the seashore in Belgium, a laboratory-generated SSA, the marine algal toxin homoyessotoxin and a chemical inhibitor of the mammalian target of rapamycin (mTOR) pathway. We observed significant increased expression of genes related to the mTOR pathway and Proprotein convertase subtilisin/kexin type 9 (PCSK9) after exposure to homoyessotoxin and the laboratory-generated SSA. In contrast, we observed a significant decrease in gene expression in the mTOR pathway "],"journal":["Scientific reports"],"pubmed_title":["Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway."],"pmcid":["PMC6345880"],"funding_grant_id":["12H8116N"],"pubmed_authors":["Van Acker E","Mees J","De Schamphelaere KAC","Asselman J","Tilleman L","De Rijcke M","Van Nieuwerburgh F","Janssen CR"],"additional_accession":[]},"is_claimable":false,"name":"Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway.","description":"Sea spray aerosols (SSAs) have profound effects on our climate and ecosystems. They also contain microbiota and biogenic molecules which could affect human health. Yet the exposure and effects of SSAs on human health remain poorly studied. Here, we exposed human lung cancer cells to extracts of a natural sea spray aerosol collected at the seashore in Belgium, a laboratory-generated SSA, the marine algal toxin homoyessotoxin and a chemical inhibitor of the mammalian target of rapamycin (mTOR) pathway. We observed significant increased expression of genes related to the mTOR pathway and Proprotein convertase subtilisin/kexin type 9 (PCSK9) after exposure to homoyessotoxin and the laboratory-generated SSA. In contrast, we observed a significant decrease in gene expression in the mTOR pathway ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2026-07-16T17:11:21.746Z","creation":"2019-03-26T22:41:53Z"},"accession":"S-EPMC6345880","cross_references":{"pubmed":["30679557"],"doi":["10.1038/s41598-018-36866-3"]}}