{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Su Q"],"funding":["Natural Science Foundation of Guangxi Province","National Natural Science Foundation of China"],"pagination":["61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6347606"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(2)"],"pubmed_abstract":["Coronary microembolization (CME) is a common complication seen during primary percutaneous coronary intervention (pPCI). CME-induced myocardiac inflammation is the primary cause of myocardiac injury. Dysregulated miR-142-3p has been implicated in multiple cardiovascular diseases and is significantly downregulated in CME-induced myocardial injury. However, the role of miR-142-3p in CME-induced myocardial injury is unclear. This study herein built a porcine CME model by infusing microembolization spheres into the left anterior descending branch via a microcatheter, and detected the downregulation of miR-142-3p in the myocardial tissues of CME pigs. Echocardiography, hematoxylin basic fuchsin picric acid (HBFP) staining, and western blotting of NF-κB p65, TNF-α, IL-1β, and IL-6 showed that th"],"journal":["Cell death & disease"],"pubmed_title":["The mechanism of miR-142-3p in coronary microembolization-induced myocardiac injury via regulating target gene IRAK-1."],"pmcid":["PMC6347606"],"funding_grant_id":["2016GXNSFBA380022","81600283"],"pubmed_authors":["Su Q","Kong B","Lv X","Qin Z","Sun Y","Li L","Ye Z"],"additional_accession":[]},"is_claimable":false,"name":"The mechanism of miR-142-3p in coronary microembolization-induced myocardiac injury via regulating target gene IRAK-1.","description":"Coronary microembolization (CME) is a common complication seen during primary percutaneous coronary intervention (pPCI). CME-induced myocardiac inflammation is the primary cause of myocardiac injury. Dysregulated miR-142-3p has been implicated in multiple cardiovascular diseases and is significantly downregulated in CME-induced myocardial injury. However, the role of miR-142-3p in CME-induced myocardial injury is unclear. This study herein built a porcine CME model by infusing microembolization spheres into the left anterior descending branch via a microcatheter, and detected the downregulation of miR-142-3p in the myocardial tissues of CME pigs. Echocardiography, hematoxylin basic fuchsin picric acid (HBFP) staining, and western blotting of NF-κB p65, TNF-α, IL-1β, and IL-6 showed that th","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2025-05-29T22:27:58.343Z","creation":"2025-05-29T22:27:58.343Z"},"accession":"S-EPMC6347606","cross_references":{"pubmed":["30683933"],"doi":["10.1038/s41419-019-1341-7"]}}