biostudies-literatureSu QNatural Science Foundation of Guangxi ProvinceNational Natural Science Foundation of China61https://www.ebi.ac.uk/biostudies/studies/S-EPMC6347606biostudies-literatureUnknown10(2)Coronary microembolization (CME) is a common complication seen during primary percutaneous coronary intervention (pPCI). CME-induced myocardiac inflammation is the primary cause of myocardiac injury. Dysregulated miR-142-3p has been implicated in multiple cardiovascular diseases and is significantly downregulated in CME-induced myocardial injury. However, the role of miR-142-3p in CME-induced myocardial injury is unclear. This study herein built a porcine CME model by infusing microembolization spheres into the left anterior descending branch via a microcatheter, and detected the downregulation of miR-142-3p in the myocardial tissues of CME pigs. Echocardiography, hematoxylin basic fuchsin picric acid (HBFP) staining, and western blotting of NF-κB p65, TNF-α, IL-1β, and IL-6 showed that thCell death & diseaseThe mechanism of miR-142-3p in coronary microembolization-induced myocardiac injury via regulating target gene IRAK-1.PMC63476062016GXNSFBA38002281600283Su QKong BLv XQin ZSun YLi LYe ZfalseThe mechanism of miR-142-3p in coronary microembolization-induced myocardiac injury via regulating target gene IRAK-1.Coronary microembolization (CME) is a common complication seen during primary percutaneous coronary intervention (pPCI). CME-induced myocardiac inflammation is the primary cause of myocardiac injury. Dysregulated miR-142-3p has been implicated in multiple cardiovascular diseases and is significantly downregulated in CME-induced myocardial injury. However, the role of miR-142-3p in CME-induced myocardial injury is unclear. This study herein built a porcine CME model by infusing microembolization spheres into the left anterior descending branch via a microcatheter, and detected the downregulation of miR-142-3p in the myocardial tissues of CME pigs. Echocardiography, hematoxylin basic fuchsin picric acid (HBFP) staining, and western blotting of NF-κB p65, TNF-α, IL-1β, and IL-6 showed that th2019-01-01T00:00:00Z2019 Jan2025-05-29T22:27:58.343Z2025-05-29T22:27:58.343ZS-EPMC63476063068393310.1038/s41419-019-1341-7