{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ding D"],"funding":["NEI NIH HHS","Foundation for the National Institutes of Health","U.S. Department of Defense","NINDS NIH HHS"],"pagination":["2618-2639"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6348056"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["56(4)"],"pubmed_abstract":["Neurons from the adult central nervous system (CNS) demonstrate limited mRNA transport and localized protein synthesis versus developing neurons, correlating with lower regenerative capacity. We found that deimination (posttranslational conversion of protein-bound arginine into citrulline) undergoes upregulation during early neuronal development while declining to a low basal level in adults. This modification is associated with neuronal arborization from amphibians to mammals. The mRNA-binding proteins (ANP32a, REF), deiminated in neurons, have been implicated in local protein synthesis. Overexpression of the deiminating cytosolic enzyme peptidyl arginine deiminase 2 in nervous systems results in increased neuronal transport and neurite outgrowth. We further demonstrate that enriching dei"],"journal":["Molecular neurobiology"],"pubmed_title":["The Role of Deimination in Regenerative Reprogramming of Neurons."],"pmcid":["PMC6348056"],"funding_grant_id":["R01 NS034773","R29 NS034773","U01 EY027257","U01EY027257","R01 EY019077","W81XWH-16-1-0715","EY014957","R01 NS097658","NS034773","RF1 NS034773","P30 EY014801","R01 EY014957","EY019077"],"pubmed_authors":["Chou TH","Bhattacharya SK","Ding D","Perez-Pinzon M","Nestler E","Torres J","Pole C","Udin S","Enriquez-Algeciras M","Thompson JW","Valdivia AO","Porciatti V"],"additional_accession":[]},"is_claimable":false,"name":"The Role of Deimination in Regenerative Reprogramming of Neurons.","description":"Neurons from the adult central nervous system (CNS) demonstrate limited mRNA transport and localized protein synthesis versus developing neurons, correlating with lower regenerative capacity. We found that deimination (posttranslational conversion of protein-bound arginine into citrulline) undergoes upregulation during early neuronal development while declining to a low basal level in adults. This modification is associated with neuronal arborization from amphibians to mammals. The mRNA-binding proteins (ANP32a, REF), deiminated in neurons, have been implicated in local protein synthesis. Overexpression of the deiminating cytosolic enzyme peptidyl arginine deiminase 2 in nervous systems results in increased neuronal transport and neurite outgrowth. We further demonstrate that enriching dei","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2026-04-18T15:04:15.257Z","creation":"2020-05-22T14:46:51Z"},"accession":"S-EPMC6348056","cross_references":{"pubmed":["30051351"],"doi":["10.1007/s12035-018-1262-y"]}}