biostudies-literatureKumar MEuropean Research CouncilEngineering and Physical Sciences Research Council16753-16756https://www.ebi.ac.uk/biostudies/studies/S-EPMC6348375biostudies-literatureUnknown24(63)The inthomycins are a family of structurally and biologically rich natural products isolated from Streptomyces species. Herein the implementation of a modular synthetic route is reported that has enabled the enantioselective synthesis of all three inthomycins. Key steps include Suzuki and Sonogashira cross-couplings and an enantioselective Kiyooka aldol reaction.Chemistry (Weinheim an der Bergstrasse, Germany)Short, Tin-Free Synthesis of All Three Inthomycins.PMC6348375708354EP/J004499/1Anderson ZKumar MOvery ABurton JWBromhead LfalseShort, Tin-Free Synthesis of All Three Inthomycins.The inthomycins are a family of structurally and biologically rich natural products isolated from Streptomyces species. Herein the implementation of a modular synthetic route is reported that has enabled the enantioselective synthesis of all three inthomycins. Key steps include Suzuki and Sonogashira cross-couplings and an enantioselective Kiyooka aldol reaction.2018-01-01T00:00:00Z2018 Nov2026-05-07T06:29:22.162Z2025-05-29T22:28:48.278ZS-EPMC63483753033858710.1002/chem.201803794