{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kageyama S"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","NIEHS NIH HHS","NCI NIH HHS","National Institutes of Health","CSR NIH HHS","Center for Scientific Review"],"pagination":["356-367"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6349504"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(2)"],"pubmed_abstract":["By documenting potent antioxidative and anti-inflammatory functions, preclinical studies encourage heme oxygenase-1 (HO-1)-inducing regimens in clinical orthotopic liver transplantation (OLT). We aimed to determine the importance of recipient-derived HO-1 in murine and human OLTs. Hepatic biopsies from 51 OLT patients were screened for HO-1 expression (Western blots) prior to put-in (basal) and post reperfusion (stressed) and correlated with the hepatocellular function. In parallel, livers from HO-1 proficient mice (WT; C57/BL6), subjected to ex vivo cold storage (18 hour), were transplanted to syngeneic myeloid HO-1 deficient (mHO-1 KO) or FLOX (control) hosts, and sampled postreperfusion (6 hour). In human OLT, posttransplant but not pretransplant HO-1 expression correlated negatively wi"],"journal":["American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"],"pubmed_title":["Recipient HO-1 inducibility is essential for posttransplant hepatic HO-1 expression and graft protection: From bench-to-bedside."],"pmcid":["PMC6349504"],"funding_grant_id":["RO1 ES016959","P01 AI120944","T32 CA009120","R01 ES016959","RO1 DK062357","R01 DK102110","R01 DK107533","R56 ES016959","R56 ES016959-06","DK102110","DK107533","PO1 AI120944","R01 DK062357"],"pubmed_authors":["Busuttil RW","Ito T","Nakamura K","Hirao H","Kageyama S","Kaldas FM","Zhang M","Oncel D","Sosa RA","Aziz A","Kupiec-Weglinski JW","Reed EF","Ke B","Araujo JA"],"additional_accession":[]},"is_claimable":false,"name":"Recipient HO-1 inducibility is essential for posttransplant hepatic HO-1 expression and graft protection: From bench-to-bedside.","description":"By documenting potent antioxidative and anti-inflammatory functions, preclinical studies encourage heme oxygenase-1 (HO-1)-inducing regimens in clinical orthotopic liver transplantation (OLT). We aimed to determine the importance of recipient-derived HO-1 in murine and human OLTs. Hepatic biopsies from 51 OLT patients were screened for HO-1 expression (Western blots) prior to put-in (basal) and post reperfusion (stressed) and correlated with the hepatocellular function. In parallel, livers from HO-1 proficient mice (WT; C57/BL6), subjected to ex vivo cold storage (18 hour), were transplanted to syngeneic myeloid HO-1 deficient (mHO-1 KO) or FLOX (control) hosts, and sampled postreperfusion (6 hour). In human OLT, posttransplant but not pretransplant HO-1 expression correlated negatively wi","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2025-04-26T10:41:11.92Z","creation":"2020-05-22T08:45:33Z"},"accession":"S-EPMC6349504","cross_references":{"pubmed":["30059195"],"doi":["10.1111/ajt.15043"]}}