{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Grande R"],"funding":["Irish Research Council","Associazione Italiana per la Ricerca sul Cancro","Science Foundation Ireland"],"pubmed_abstract":["<b>Rationale:</b> Obesity is a risk factor for atherothrombosis and various cancers. However, the mechanisms are not yet completely clarified. <b>Objectives:</b> We aimed to verify whether the microparticles (MPs) released from thrombin-activated platelets differed in obese and non-obese women for number, size, and proteomics cargo and the capacity to modulate <i>in vitro</i> the expression of (i) genes related to the epithelial to mesenchymal transition (EMT) and the endothelial to mesenchymal transition (EndMT), and (ii) cyclooxygenase (COX)-2 involved in the production of angiogenic and inflammatory mediators. <b>Methods and Results:</b> MPs were obtained from thrombin activated platelets of four obese and their matched non-obese women. MPs were analyzed by cytofluorimeter and protein c"],"journal":["Frontiers in pharmacology"],"pagination":["7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6349702"],"repository":["biostudies-literature"],"pubmed_title":["Platelet-Derived Microparticles From Obese Individuals: Characterization of Number, Size, Proteomics, and Crosstalk With Cancer and Endothelial Cells."],"pmcid":["PMC6349702"],"pubmed_authors":["Maguire PB","Szklanna PB","Patrignani P","Marchisio M","Dovizio M","Bruno A","Lanuti P","Cassidy H","Mingrone G","Caprodossi A","Grande R","Marcone S","Ni Ainle F","Ebhardt HA"],"additional_accession":[]},"is_claimable":false,"name":"Platelet-Derived Microparticles From Obese Individuals: Characterization of Number, Size, Proteomics, and Crosstalk With Cancer and Endothelial Cells.","description":"<b>Rationale:</b> Obesity is a risk factor for atherothrombosis and various cancers. However, the mechanisms are not yet completely clarified. <b>Objectives:</b> We aimed to verify whether the microparticles (MPs) released from thrombin-activated platelets differed in obese and non-obese women for number, size, and proteomics cargo and the capacity to modulate <i>in vitro</i> the expression of (i) genes related to the epithelial to mesenchymal transition (EMT) and the endothelial to mesenchymal transition (EndMT), and (ii) cyclooxygenase (COX)-2 involved in the production of angiogenic and inflammatory mediators. <b>Methods and Results:</b> MPs were obtained from thrombin activated platelets of four obese and their matched non-obese women. MPs were analyzed by cytofluorimeter and protein c","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-04-29T21:06:47.886Z","creation":"2026-04-07T15:31:48.643Z"},"accession":"S-EPMC6349702","cross_references":{"pubmed":["30723407"],"doi":["10.3389/fphar.2019.00007"]}}