biostudies-literatureUnknown10Grande RIrish Research CouncilAssociazione Italiana per la Ricerca sul CancroScience Foundation Ireland<b>Rationale:</b> Obesity is a risk factor for atherothrombosis and various cancers. However, the mechanisms are not yet completely clarified. <b>Objectives:</b> We aimed to verify whether the microparticles (MPs) released from thrombin-activated platelets differed in obese and non-obese women for number, size, and proteomics cargo and the capacity to modulate <i>in vitro</i> the expression of (i) genes related to the epithelial to mesenchymal transition (EMT) and the endothelial to mesenchymal transition (EndMT), and (ii) cyclooxygenase (COX)-2 involved in the production of angiogenic and inflammatory mediators. <b>Methods and Results:</b> MPs were obtained from thrombin activated platelets of four obese and their matched non-obese women. MPs were analyzed by cytofluorimeter and protein cFrontiers in pharmacology7https://www.ebi.ac.uk/biostudies/studies/S-EPMC6349702biostudies-literaturePlatelet-Derived Microparticles From Obese Individuals: Characterization of Number, Size, Proteomics, and Crosstalk With Cancer and Endothelial Cells.PMC6349702Maguire PBSzklanna PBPatrignani PMarchisio MDovizio MBruno ALanuti PCassidy HMingrone GCaprodossi AGrande RMarcone SNi Ainle FEbhardt HAfalsePlatelet-Derived Microparticles From Obese Individuals: Characterization of Number, Size, Proteomics, and Crosstalk With Cancer and Endothelial Cells.<b>Rationale:</b> Obesity is a risk factor for atherothrombosis and various cancers. However, the mechanisms are not yet completely clarified. <b>Objectives:</b> We aimed to verify whether the microparticles (MPs) released from thrombin-activated platelets differed in obese and non-obese women for number, size, and proteomics cargo and the capacity to modulate <i>in vitro</i> the expression of (i) genes related to the epithelial to mesenchymal transition (EMT) and the endothelial to mesenchymal transition (EndMT), and (ii) cyclooxygenase (COX)-2 involved in the production of angiogenic and inflammatory mediators. <b>Methods and Results:</b> MPs were obtained from thrombin activated platelets of four obese and their matched non-obese women. MPs were analyzed by cytofluorimeter and protein c2019-01-01T00:00:00Z20192026-04-29T21:06:47.886Z2026-04-07T15:31:48.643ZS-EPMC63497023072340710.3389/fphar.2019.00007