{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(3)"],"submitter":["Catacchio I"],"pubmed_abstract":["BACKGROUND:Tumor infiltrating lymphocytes (TILs) are widely considered a key sign of the immune interaction between host and tumor, and potentially prognostic biomarkers of good or bad outcome in many cancers, included invasive breast cancer (BC). However, results about the association between TIL typology, location and BC prognosis, are controversial. The aim of the study was to evaluated the prognostic significance of TIL subtypes (CD4+, CD8+, FOXP3+ T cells) and their location (stromal \"s\" and intratumoral \"i\" CD4+ and CD8+) in BC patients, focusing on the association between these markers and immunocheckpoint molecules such as cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell death ligand 1 (PD-L1) and its receptor (PD-1). METHODS:CD4+, CD8+, FOXP3+, CTLA4+, PD-L1+ and PD-1+ e"],"journal":["Translational oncology"],"pagination":["585-595"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6350084"],"repository":["biostudies-literature"],"pubmed_title":["Intratumoral, rather than stromal, CD8+ T cells could be a potential negative prognostic marker in invasive breast cancer patients."],"pmcid":["PMC6350084"],"pubmed_authors":["Scarpi E","Schirosi L","Catacchio I","Scattone A","Silvestris N","Mangia A"],"additional_accession":[]},"is_claimable":false,"name":"Intratumoral, rather than stromal, CD8+ T cells could be a potential negative prognostic marker in invasive breast cancer patients.","description":"BACKGROUND:Tumor infiltrating lymphocytes (TILs) are widely considered a key sign of the immune interaction between host and tumor, and potentially prognostic biomarkers of good or bad outcome in many cancers, included invasive breast cancer (BC). However, results about the association between TIL typology, location and BC prognosis, are controversial. The aim of the study was to evaluated the prognostic significance of TIL subtypes (CD4+, CD8+, FOXP3+ T cells) and their location (stromal \"s\" and intratumoral \"i\" CD4+ and CD8+) in BC patients, focusing on the association between these markers and immunocheckpoint molecules such as cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell death ligand 1 (PD-L1) and its receptor (PD-1). METHODS:CD4+, CD8+, FOXP3+, CTLA4+, PD-L1+ and PD-1+ e","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2025-04-26T11:17:49.135Z","creation":"2019-03-26T22:47:46Z"},"accession":"S-EPMC6350084","cross_references":{"pubmed":["30682679"],"doi":["10.1016/j.tranon.2018.12.005"]}}