{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liao MZ"],"funding":["NCATS NIH HHS","NICHD NIH HHS","NIDA NIH HHS"],"pagination":["145-152"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6350206"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(2)"],"pubmed_abstract":["<h4>Background</h4>Few studies have systematically investigated pregnancy-induced changes in protein abundance of drug transporters in organs important for drug/xenobiotic disposition.<h4>Objective</h4>The goal of this study was to compare protein abundance of important drug/xenobiotic transporters including Abcb1a, Abcg2, Abcc2, and Slco1b2 in the liver, kidney and brain of pregnant mice on gestation day 15 to that of non-pregnant mice.<h4>Methods</h4>The mass spectrometry-based proteomics was used to quantify changes in protein abundance of transporters in tissues from pregnant and non-pregnant mice.<h4>Results</h4>The protein levels of hepatic Abcc2, Abcc3, and Slco1a4 per μg of total membrane proteins were significantly decreased by pregnancy by 24%, 72%, and 70%, respectively. The pro"],"journal":["Drug metabolism letters"],"pubmed_title":["Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy."],"pmcid":["PMC6350206"],"funding_grant_id":["R01 HD081299","TL1 TR000422","P01 DA032507"],"pubmed_authors":["Liao MZ","Prasad B","Mao Q","Gao C","Bhatt DK"],"additional_accession":[]},"is_claimable":false,"name":"Quantitative Proteomics Reveals Changes in Transporter Protein Abundance in Liver, Kidney and Brain of Mice by Pregnancy.","description":"<h4>Background</h4>Few studies have systematically investigated pregnancy-induced changes in protein abundance of drug transporters in organs important for drug/xenobiotic disposition.<h4>Objective</h4>The goal of this study was to compare protein abundance of important drug/xenobiotic transporters including Abcb1a, Abcg2, Abcc2, and Slco1b2 in the liver, kidney and brain of pregnant mice on gestation day 15 to that of non-pregnant mice.<h4>Methods</h4>The mass spectrometry-based proteomics was used to quantify changes in protein abundance of transporters in tissues from pregnant and non-pregnant mice.<h4>Results</h4>The protein levels of hepatic Abcc2, Abcc3, and Slco1a4 per μg of total membrane proteins were significantly decreased by pregnancy by 24%, 72%, and 70%, respectively. The pro","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2026-07-16T20:46:03.173Z","creation":"2026-07-10T03:12:04.866Z"},"accession":"S-EPMC6350206","cross_references":{"pubmed":["29938623"],"doi":["10.2174/1872312812666180625122810"]}}