biostudies-literatureUnknown9(1)Lapteva MMonoclonal antibodies targeting cytokines are administered parenterally for the systemic treatment of severe psoriasis. However, systemic exposure to the biologic increases the risk of side-effects including immunosuppression, whereas only a small fraction of the active molecules actually reaches the target organ, the skin. This preclinical study examines the feasibility of delivering a humanized anti-CD29 monoclonal antibody (OS2966) topically to skin using minimally-invasive fractional laser ablation. This approach would enable the targeted use of a biologic for the treatment of recalcitrant psoriatic plaques in patients with less widespread disease while minimizing the risk of systemic exposure. First, the effect of a wide range of laser poration conditions on skin permeation and deposiScientific reports1030https://www.ebi.ac.uk/biostudies/studies/S-EPMC6355906biostudies-literatureFractional laser ablation for the targeted cutaneous delivery of an anti-CD29 monoclonal antibody - OS2966.PMC6355906Lapteva MKalia YNWu EDel Rio-Sancho SBohler CCarbonell WSfalseFractional laser ablation for the targeted cutaneous delivery of an anti-CD29 monoclonal antibody - OS2966.Monoclonal antibodies targeting cytokines are administered parenterally for the systemic treatment of severe psoriasis. However, systemic exposure to the biologic increases the risk of side-effects including immunosuppression, whereas only a small fraction of the active molecules actually reaches the target organ, the skin. This preclinical study examines the feasibility of delivering a humanized anti-CD29 monoclonal antibody (OS2966) topically to skin using minimally-invasive fractional laser ablation. This approach would enable the targeted use of a biologic for the treatment of recalcitrant psoriatic plaques in patients with less widespread disease while minimizing the risk of systemic exposure. First, the effect of a wide range of laser poration conditions on skin permeation and deposi2019-01-01T00:00:00Z2019 Jan2026-05-06T21:50:54.231Z2019-03-26T22:47:52ZS-EPMC63559063070529310.1038/s41598-018-36966-0