{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luo J"],"funding":["NSFC-Shandong Joint Fund","Qingdao Marine Biomedical Science and Technology Innovation Center project","Key Research Program of Frontier Sciences, CAS","Shandong Provincial Natural Science Foundation for Distinguished Young Scholars","Key research and development project of Shandong province"],"pagination":["E49"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6356253"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["RNA-binding proteins (RBPs) lie at the center of posttranscriptional regulation and the dysregulation of RBPs contributes to diabetes. Therefore, the modulation of RBPs is anticipated to become a potential therapeutic approach to diabetes. CYC27 is a synthetic derivative of marine bromophenol BDB, which is isolated from red alga <i>Rhodomela confervoides</i>. In this study, we found that CYC27 significantly lowered the blood glucose levels of diabetic BKS db mice. Moreover, CYC27 effectively ameliorated dyslipidemia in BKS db mice by reducing their total serum cholesterol (TC) and triglyceride (TG) levels. Furthermore, CYC27 was an insulin-sensitizing agent with increased insulin-stimulated phosphorylation of insulin receptors and relevant downstream factors. Finally, to systemically study"],"journal":["Marine drugs"],"pubmed_title":["CYC27 Synthetic Derivative of Bromophenol from Red Alga <i>Rhodomela confervoides</i>: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs."],"pmcid":["PMC6356253"],"funding_grant_id":["2018GSF118208","2016ZDJS07A13","QYZDB-SSW-DQC014","JQ201722","2017-CXZX01-1-1","U1706213","2017-CXZX01-3-9"],"pubmed_authors":["Li C","Luo J","Jiang B","Jia X","Shi D"],"additional_accession":[]},"is_claimable":false,"name":"CYC27 Synthetic Derivative of Bromophenol from Red Alga <i>Rhodomela confervoides</i>: Anti-Diabetic Effects of Sensitizing Insulin Signaling Pathways and Modulating RNA Splicing-Associated RBPs.","description":"RNA-binding proteins (RBPs) lie at the center of posttranscriptional regulation and the dysregulation of RBPs contributes to diabetes. Therefore, the modulation of RBPs is anticipated to become a potential therapeutic approach to diabetes. CYC27 is a synthetic derivative of marine bromophenol BDB, which is isolated from red alga <i>Rhodomela confervoides</i>. In this study, we found that CYC27 significantly lowered the blood glucose levels of diabetic BKS db mice. Moreover, CYC27 effectively ameliorated dyslipidemia in BKS db mice by reducing their total serum cholesterol (TC) and triglyceride (TG) levels. Furthermore, CYC27 was an insulin-sensitizing agent with increased insulin-stimulated phosphorylation of insulin receptors and relevant downstream factors. Finally, to systemically study","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2025-04-21T18:48:04.341Z","creation":"2020-11-19T11:17:09Z"},"accession":"S-EPMC6356253","cross_references":{"pubmed":["30641913"],"doi":["10.3390/md17010049"]}}