biostudies-literatureMonteleone EAssociazione Italiana per la Ricerca sul CancroMinistero dell'Istruzione, dell'Università e della RicercaMinistero dell’Istruzione, dell’Università e della RicercaFondazione CRTTruus and Gerrit van Riemsdijk Foundation, LiechtensteinCompagnia di San PaoloE101https://www.ebi.ac.uk/biostudies/studies/S-EPMC6356433biostudies-literatureUnknown11(1)Breast cancer is a heterogeneous disease whose clinical management is very challenging. Although specific molecular features characterize breast cancer subtypes with different prognosis, the identification of specific markers predicting disease outcome within the single subtypes still lags behind. Both the non-canonical Wingless-type MMTV Integration site (WNT) and the Signal Transducer and Activator of Transcription (STAT)3 pathways are often constitutively activated in breast tumors, and both can induce the small GTPase Ras Homolog Family Member U <i>RhoU</i>. Here we show that <i>RhoU</i> transcription can be triggered by both canonical and non-canonical WNT ligands via the activation of c-JUN N-terminal kinase (JNK) and the recruitment of the Specificity Protein 1 (SP1) transcription fCancersSP1 and STAT3 Functionally Synergize to Induce the <i>RhoU</i> Small GTPase and a Subclass of Non-canonical WNT Responsive Genes Correlating with Poor Prognosis in Breast Cancer.PMC6356433IG13009VP1IG16930PRIN 2012 9JLHSYVP02_2012_006202_2012_0094PRIN 2015 YYLBTRPoli VAvalle LMolineris IProvero PSavino AOrecchia VSchiavone DCorrieri PMonteleone EMoiso EfalseSP1 and STAT3 Functionally Synergize to Induce the <i>RhoU</i> Small GTPase and a Subclass of Non-canonical WNT Responsive Genes Correlating with Poor Prognosis in Breast Cancer.Breast cancer is a heterogeneous disease whose clinical management is very challenging. Although specific molecular features characterize breast cancer subtypes with different prognosis, the identification of specific markers predicting disease outcome within the single subtypes still lags behind. Both the non-canonical Wingless-type MMTV Integration site (WNT) and the Signal Transducer and Activator of Transcription (STAT)3 pathways are often constitutively activated in breast tumors, and both can induce the small GTPase Ras Homolog Family Member U <i>RhoU</i>. Here we show that <i>RhoU</i> transcription can be triggered by both canonical and non-canonical WNT ligands via the activation of c-JUN N-terminal kinase (JNK) and the recruitment of the Specificity Protein 1 (SP1) transcription f2019-01-01T00:00:00Z2019 Jan2026-07-09T12:10:35.879Z2019-03-26T22:47:54ZS-EPMC63564333065451810.3390/cancers11010101