{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(2)"],"submitter":["Sun HJ"],"pubmed_abstract":["Neuroinflammation has been well recognized as a key pathological event in acute glaucoma. The medical therapy of acute glaucoma mainly focuses on lowering intraocular pressure (IOP), while there are still scarce anti-inflammatory agents in the clinical treatment of acute glaucoma. Here we reported that β,3α,5α-trihydroxy-androst-6-one (sterone), a novel synthetic polyhydric steroid, blocked neuroinflammation mediated by microglia/macrophages and alleviated the loss of retinal ganglion cells (RGCs) caused by acute intraocular hypertension (AIH). The results showed that sterone significantly inhibited the morphological changes, the up-regulation of inflammatory biomarker ionized calcium-binding adapter molecule 1 (Iba-1), and the mRNA increase of proinflammatory tumor necrosis factor-α (TNF-"],"journal":["Molecules (Basel, Switzerland)"],"pagination":["E252"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6358879"],"repository":["biostudies-literature"],"pubmed_title":["A Novel Synthetic Steroid of 2β,3α,5α-Trihydroxy-androst-6-one Alleviates the Loss of Rat Retinal Ganglion Cells Caused by Acute Intraocular Hypertension via Inhibiting the Inflammatory Activation of Microglia."],"pmcid":["PMC6358879"],"pubmed_authors":["Yin W","Sheng LX","Zhu Z","Yan GM","Lu BZ","Zhou YW","Xue DD","Li Y","Chen YP","Sun HJ","Zhang JX","Lin GJ","Lin SZ"],"additional_accession":[]},"is_claimable":false,"name":"A Novel Synthetic Steroid of 2β,3α,5α-Trihydroxy-androst-6-one Alleviates the Loss of Rat Retinal Ganglion Cells Caused by Acute Intraocular Hypertension via Inhibiting the Inflammatory Activation of Microglia.","description":"Neuroinflammation has been well recognized as a key pathological event in acute glaucoma. The medical therapy of acute glaucoma mainly focuses on lowering intraocular pressure (IOP), while there are still scarce anti-inflammatory agents in the clinical treatment of acute glaucoma. Here we reported that β,3α,5α-trihydroxy-androst-6-one (sterone), a novel synthetic polyhydric steroid, blocked neuroinflammation mediated by microglia/macrophages and alleviated the loss of retinal ganglion cells (RGCs) caused by acute intraocular hypertension (AIH). The results showed that sterone significantly inhibited the morphological changes, the up-regulation of inflammatory biomarker ionized calcium-binding adapter molecule 1 (Iba-1), and the mRNA increase of proinflammatory tumor necrosis factor-α (TNF-","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2025-04-18T16:31:53.252Z","creation":"2019-03-26T22:53:18Z"},"accession":"S-EPMC6358879","cross_references":{"pubmed":["30641903"],"doi":["10.3390/molecules24020252"]}}