{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gutierrez-Zetina SM"],"funding":["Interreg","Ministerio de Economía y Competitividad"],"pagination":["E307"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6359441"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(2)"],"pubmed_abstract":["Protocatechuic acid (3,4-dihydroxybenzoic acid; PCA) is a phenolic acid present in plants as a secondary metabolite and is also produced in the human organism as a metabolite from the degradation of polyphenols by the intestinal microbiota, particularly of flavonoids. However, PCA, like most polyphenols, is biotransformed in the human body to different conjugates as sulfates, which are found circulating in blood and could be involved in the bioactivity of the original compound. This paper describes a simple process for the preparation of PCA monosulfates with satisfactory yields. Two compounds were obtained that were identified as PCA-3-sulfate and PCA-4-sulfate by mass spectrometry and ¹H and <sup>13</sup>C nuclear magnetic resonance using one- and two-dimensional techniques (heteronuclea"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Preparation and Characterization of Protocatechuic Acid Sulfates."],"pmcid":["PMC6359441"],"funding_grant_id":["AGL2015-64522-C2-R","0377_IBERPHENOL_6_E"],"pubmed_authors":["Gonzalez-Paramas AM","Gutierrez-Zetina SM","Santos-Buelga C","Perez-Alonso JJ","Gonzalez-Manzano S"],"additional_accession":[]},"is_claimable":false,"name":"Preparation and Characterization of Protocatechuic Acid Sulfates.","description":"Protocatechuic acid (3,4-dihydroxybenzoic acid; PCA) is a phenolic acid present in plants as a secondary metabolite and is also produced in the human organism as a metabolite from the degradation of polyphenols by the intestinal microbiota, particularly of flavonoids. However, PCA, like most polyphenols, is biotransformed in the human body to different conjugates as sulfates, which are found circulating in blood and could be involved in the bioactivity of the original compound. This paper describes a simple process for the preparation of PCA monosulfates with satisfactory yields. Two compounds were obtained that were identified as PCA-3-sulfate and PCA-4-sulfate by mass spectrometry and ¹H and <sup>13</sup>C nuclear magnetic resonance using one- and two-dimensional techniques (heteronuclea","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2026-07-09T12:15:25.512Z","creation":"2025-05-29T22:26:39.949Z"},"accession":"S-EPMC6359441","cross_references":{"pubmed":["30654476"],"doi":["10.3390/molecules24020307"]}}