biostudies-literatureUnknown10Bhusal ADiabetic encephalopathy is a severe diabetes-related complication in the central nervous system (CNS) that is characterized by degenerative neurochemical and structural changes leading to impaired cognitive function. While the exact pathophysiology of diabetic encephalopathy is not well-understood, it is likely that neuroinflammation is one of the key pathogenic mechanisms that cause this complication. Lipocalin-2 (LCN2) is an acute phase protein known to promote neuroinflammation via the recruitment and activation of immune cells and glia, particularly microglia and astrocytes, thereby inducing proinflammatory mediators in a range of neurological disorders. In this study, we investigated the role of LCN2 in multiple aspects of diabetic encephalopathy in mouse models of diabetes. Here, we Frontiers in endocrinology25https://www.ebi.ac.uk/biostudies/studies/S-EPMC6363678biostudies-literatureRole of Hippocampal Lipocalin-2 in Experimental Diabetic Encephalopathy.PMC6363678Rahman MHLee IKSuk KBhusal AfalseRole of Hippocampal Lipocalin-2 in Experimental Diabetic Encephalopathy.Diabetic encephalopathy is a severe diabetes-related complication in the central nervous system (CNS) that is characterized by degenerative neurochemical and structural changes leading to impaired cognitive function. While the exact pathophysiology of diabetic encephalopathy is not well-understood, it is likely that neuroinflammation is one of the key pathogenic mechanisms that cause this complication. Lipocalin-2 (LCN2) is an acute phase protein known to promote neuroinflammation via the recruitment and activation of immune cells and glia, particularly microglia and astrocytes, thereby inducing proinflammatory mediators in a range of neurological disorders. In this study, we investigated the role of LCN2 in multiple aspects of diabetic encephalopathy in mouse models of diabetes. Here, we 2019-01-01T00:00:00Z20192025-06-01T02:33:39.463Z2019-03-26T22:55:30ZS-EPMC63636783076108810.3389/fendo.2019.00025