{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Herath HMPD"],"funding":["University of Melbourne","Super Science Initiative and the Peter MacCallum Cancer Centre Foundation","Medicines for Malaria Venture (MMV)","Yourgene Bioscience and The University of Melbourne","Australian Government’s Education Investment","Australian Research Council"],"pagination":["72-79"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6369141"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["Due to the widespread occurrence and spread of anthelmintic resistance, there is a need to develop new drugs against resistant parasitic nematodes of livestock animals. The Nobel Prize-winning discovery and development of the anti-parasitic drugs avermectin and artemisinin has renewed the interest in exploring natural products as anthelmintics. In the present study, we screened 7500 plant extracts for in vitro-activity against the barber's pole worm, Haemonchus contortus, a highly significant pathogen of ruminants. The anthelmintic extracts from two plants, Cryptocarya novoguineensis and Piper methysticum, were fractionated by high-performance liquid chromatography (HPLC). Subsequently, compounds were purified from fractions with significant biological activity. Four α-pyrones, namely goni"],"journal":["International journal for parasitology. Drugs and drug resistance"],"pubmed_title":["Selected α-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro."],"pmcid":["PMC6369141"],"funding_grant_id":["0707258"],"pubmed_authors":["Preston S","Addison RS","Jabbar A","Davis RA","Chang BCH","Gasser RB","Rali T","Wang T","Hofmann A","Koehler AV","Herath HMPD","Hayes S","Garcia-Bustos J"],"additional_accession":[]},"is_claimable":false,"name":"Selected α-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro.","description":"Due to the widespread occurrence and spread of anthelmintic resistance, there is a need to develop new drugs against resistant parasitic nematodes of livestock animals. The Nobel Prize-winning discovery and development of the anti-parasitic drugs avermectin and artemisinin has renewed the interest in exploring natural products as anthelmintics. In the present study, we screened 7500 plant extracts for in vitro-activity against the barber's pole worm, Haemonchus contortus, a highly significant pathogen of ruminants. The anthelmintic extracts from two plants, Cryptocarya novoguineensis and Piper methysticum, were fractionated by high-performance liquid chromatography (HPLC). Subsequently, compounds were purified from fractions with significant biological activity. Four α-pyrones, namely goni","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2025-06-01T00:36:29.894Z","creation":"2025-06-01T00:36:29.894Z"},"accession":"S-EPMC6369141","cross_references":{"pubmed":["30739078"],"doi":["10.1016/j.ijpddr.2018.12.006"]}}