biostudies-literatureJanuszewicz WCancer Research UKNIDDK NIH HHSMedical Research CouncilNational Institute for Health Research (NIHR)NCI NIH HHS647-656.e1https://www.ebi.ac.uk/biostudies/studies/S-EPMC6370042biostudies-literatureUnknown17(4)<h4>Background & aims</h4>Diagnosis and surveillance of Barrett's esophagus (BE) and eosinophilic esophagitis (EoE) have become emerging public health issues. Cytosponge is a novel, minimally invasive esophageal cell collection device. We aimed to assess the data on safety and acceptability of this device.<h4>Methods</h4>We performed a patient-level review of 5 prospective trials assessing Cytosponge performance in patients with reflux disease, BE and EoE in primary and secondary care. Acceptability of Cytosponge and subsequent endoscopy were recorded with visual analogue scale (VAS), wherein 0 and 10 denoted lowest and highest acceptability. Median VAS scores were compared using a Mann-Whitney test. The number of attempts, failures in swallowing the device and occurrence of adverse eventsClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological AssociationSafety and Acceptability of Esophageal Cytosponge Cell Collection Device in a Pooled Analysis of Data From Individual Patients.PMC6370042ACF-2016-12-00112088K24 DK100548ACF-2017-14-003U54 CA163060A12088MC_UU_12022/2BEST1 and BEST2 study investigatorsLehovsky Kdi Pietro MJanuszewicz WNuckcheddy TDellon ESTan WKBoussioutas AKadri SShaheen NJKatzka DAMoist SDebiram-Beecham IFitzgerald RCfalseSafety and Acceptability of Esophageal Cytosponge Cell Collection Device in a Pooled Analysis of Data From Individual Patients.<h4>Background & aims</h4>Diagnosis and surveillance of Barrett's esophagus (BE) and eosinophilic esophagitis (EoE) have become emerging public health issues. Cytosponge is a novel, minimally invasive esophageal cell collection device. We aimed to assess the data on safety and acceptability of this device.<h4>Methods</h4>We performed a patient-level review of 5 prospective trials assessing Cytosponge performance in patients with reflux disease, BE and EoE in primary and secondary care. Acceptability of Cytosponge and subsequent endoscopy were recorded with visual analogue scale (VAS), wherein 0 and 10 denoted lowest and highest acceptability. Median VAS scores were compared using a Mann-Whitney test. The number of attempts, failures in swallowing the device and occurrence of adverse events2019-01-01T00:00:00Z2019 Mar2026-05-05T06:40:27.907Z2019-06-06T20:51:06ZS-EPMC63700423009910410.1016/j.cgh.2018.07.043