{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ricciotti E"],"funding":["NCATS NIH HHS","National Heart, Lung, and Blood Institute","National Institutes of Health"],"pagination":["e0207503"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6370185"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(2)"],"pubmed_abstract":["The cardiovascular biology of proton radiotherapy is not well understood. We aimed to compare the genomic dose-response to proton and gamma radiation of the mouse aorta to assess whether their vascular effects may diverge. We performed comparative RNA sequencing of the aorta following (4 hrs) total-body proton and gamma irradiation (0.5-200 cGy whole body dose, 10 dose levels) of conscious mice. A trend analysis identified genes that showed a dose response. While fewer genes were dose-responsive to proton than gamma radiation (29 vs. 194 genes; q-value ≤ 0.1), the magnitude of the effect was greater. Highly responsive genes were enriched for radiation response pathways (DNA damage, apoptosis, cellular stress and inflammation; p-value ≤ 0.01). Gamma, but not proton radiation induced additio"],"journal":["PloS one"],"pubmed_title":["Distinct vascular genomic response of proton and gamma radiation-A pilot investigation."],"pmcid":["PMC6370185"],"funding_grant_id":["UL1TR000003","UL1 TR000003","HL117798"],"pubmed_authors":["Krigsfeld GS","Grosser T","Kiliti AJ","Kennedy AR","Sanzari JK","Ricciotti E","Grant GR","Sarantopoulou D"],"additional_accession":[]},"is_claimable":false,"name":"Distinct vascular genomic response of proton and gamma radiation-A pilot investigation.","description":"The cardiovascular biology of proton radiotherapy is not well understood. We aimed to compare the genomic dose-response to proton and gamma radiation of the mouse aorta to assess whether their vascular effects may diverge. We performed comparative RNA sequencing of the aorta following (4 hrs) total-body proton and gamma irradiation (0.5-200 cGy whole body dose, 10 dose levels) of conscious mice. A trend analysis identified genes that showed a dose response. While fewer genes were dose-responsive to proton than gamma radiation (29 vs. 194 genes; q-value ≤ 0.1), the magnitude of the effect was greater. Highly responsive genes were enriched for radiation response pathways (DNA damage, apoptosis, cellular stress and inflammation; p-value ≤ 0.01). Gamma, but not proton radiation induced additio","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-04-08T03:36:46.364Z","creation":"2019-06-06T20:51:06Z"},"accession":"S-EPMC6370185","cross_references":{"pubmed":["30742630"],"doi":["10.1371/journal.pone.0207503"]}}