{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen L"],"funding":["National Grant Program on Key Infectious Disease","International Cooperation Project of Guangzhou Science and Technology Program"],"pagination":["483-495"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6373280"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["164(2)"],"pubmed_abstract":["Restoring antiviral immunity is a promising immunotherapeutic approach to the treatment of chronic hepatitis B virus (HBV) infection. Dendritic cells play a crucial role in triggering antiviral immunity. In this study, we identified immunodominant epitopes prevalent in CD8<sup>+</sup> T cell responses. We characterized the hierarchy of HBV epitopes targeted by CD8<sup>+</sup> T cells following autologous monocyte-derived dendritic cell (moDC) expansion in HBV-infected subjects with distinct disease stages: treatment-naïve (TN group, n = 168), treatment with complete virological response (TR group, n = 72), and resolved HBV infection (RS group, n = 28). T cell responses against 32 HBV epitopes were measured upon moDC expansion. Several subdominant epitopes that triggered HBV-specific CD8<su"],"journal":["Archives of virology"],"pubmed_title":["A novel T-cell epitope in the transmembrane region of the hepatitis B virus envelope protein responds upon dendritic cell expansion."],"pmcid":["PMC6373280"],"funding_grant_id":["2016201604030021","2014ZX10002002-002"],"pubmed_authors":["Lai J","Cao H","Huang Y","Zhang Y","Lian Y","Chen L","Chen Y","Shu X","Stamataki Z","Zhang S"],"additional_accession":[]},"is_claimable":false,"name":"A novel T-cell epitope in the transmembrane region of the hepatitis B virus envelope protein responds upon dendritic cell expansion.","description":"Restoring antiviral immunity is a promising immunotherapeutic approach to the treatment of chronic hepatitis B virus (HBV) infection. Dendritic cells play a crucial role in triggering antiviral immunity. In this study, we identified immunodominant epitopes prevalent in CD8<sup>+</sup> T cell responses. We characterized the hierarchy of HBV epitopes targeted by CD8<sup>+</sup> T cells following autologous monocyte-derived dendritic cell (moDC) expansion in HBV-infected subjects with distinct disease stages: treatment-naïve (TN group, n = 168), treatment with complete virological response (TR group, n = 72), and resolved HBV infection (RS group, n = 28). T cell responses against 32 HBV epitopes were measured upon moDC expansion. Several subdominant epitopes that triggered HBV-specific CD8<su","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2026-07-16T19:55:15.338Z","creation":"2026-07-12T03:08:37.932Z"},"accession":"S-EPMC6373280","cross_references":{"pubmed":["30415392"],"doi":["10.1007/s00705-018-4095-0"]}}