{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bodofsky S"],"funding":["Muhlenberg College","NIH Office of Research Infrastructure Programs","NIGMS NIH HHS","NIH HHS","NIGMS"],"pagination":["71-81"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6373727"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30"],"pubmed_abstract":["The nhr-67 nuclear receptor gene of Caenorhabditis elegans encodes the ortholog of the Drosophila tailless and vertebrate Tlx genes. In C. elegans, nhr-67 plays multiple roles in the development of the uterus during L2 and L3 larval stages. Four pre-VU cells are born in the L2 stage and form the precursor complement for the ventral surface of the mature uterus. One of the four pre-VU cells becomes the anchor cell (AC), which exits the cell cycle and differentiates, while the remaining three VU cells serve as stem cells that populate the ventral uterus. The nhr-67 gene functions in the development of both VU cell lineages and AC differentiation. Hypomorphic mutations in nhr-67 identify a 276bp region of the distal promoter that is sufficient to activate nhr-67 expression in pre-VU cells and"],"journal":["Gene expression patterns : GEP"],"pubmed_title":["A tissue-specific enhancer of the C. elegans nhr-67/tailless gene drives coordinated expression in uterine stem cells and the differentiated anchor cell."],"pmcid":["PMC6373727"],"funding_grant_id":["1R15GM107799","R15 GM107799","P40 OD010440"],"pubmed_authors":["Pioppo L","Birnbaum S","Lapadula D","Liberatore K","Thompson L","Kartik A","McClung G","Wightman B","Clever S","Bodofsky S"],"additional_accession":[]},"is_claimable":false,"name":"A tissue-specific enhancer of the C. elegans nhr-67/tailless gene drives coordinated expression in uterine stem cells and the differentiated anchor cell.","description":"The nhr-67 nuclear receptor gene of Caenorhabditis elegans encodes the ortholog of the Drosophila tailless and vertebrate Tlx genes. In C. elegans, nhr-67 plays multiple roles in the development of the uterus during L2 and L3 larval stages. Four pre-VU cells are born in the L2 stage and form the precursor complement for the ventral surface of the mature uterus. One of the four pre-VU cells becomes the anchor cell (AC), which exits the cell cycle and differentiates, while the remaining three VU cells serve as stem cells that populate the ventral uterus. The nhr-67 gene functions in the development of both VU cell lineages and AC differentiation. Hypomorphic mutations in nhr-67 identify a 276bp region of the distal promoter that is sufficient to activate nhr-67 expression in pre-VU cells and","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2025-04-19T01:49:39.99Z","creation":"2020-10-29T10:19:57Z"},"accession":"S-EPMC6373727","cross_references":{"pubmed":["30404043"],"doi":["10.1016/j.gep.2018.10.003"]}}