biostudies-literatureNguyen VTDutch Research Council (NWO)The Netherlands Organisation for Health Research and DevelopmentCOMPARE-H2020European CommissionWellcome Trust561-570https://www.ebi.ac.uk/biostudies/studies/S-EPMC6376849biostudies-literatureUnknown74(3)<h4>Objectives</h4>To investigate the risk of colonization with ESBL-producing Escherichia coli (ESBL-Ec) in humans in Vietnam associated with non-intensive chicken farming.<h4>Methods</h4>Faecal samples from 204 randomly selected farmers and their chickens, and from 306 age- and sex-matched community-based individuals who did not raise poultry were collected. Antimicrobial usage in chickens and humans was assessed by medicine cabinet surveys. WGS was employed to obtain a high-resolution genomic comparison between ESBL-Ec isolated from humans and chickens.<h4>Results</h4>The adjusted prevalence of ESBL-Ec colonization was 20.0% (95% CI 10.8%-29.1%) and 35.2% (95% CI 30.4%-40.1%) in chicken farms and humans in Vietnam, respectively. Colonization with ESBL-Ec in humans was associated with anThe Journal of antimicrobial chemotherapyLimited contribution of non-intensive chicken farming to ESBL-producing Escherichia coli colonization in humans in Vietnam: an epidemiological and genomic analysis.PMC6376849106680/B/14/Z643476098051110085/Z/15/Z205100012Nguyen VTCarrique-Mas JJThai QHWagenaar JAParkhill JSchultsz CThwaites GNguyen TNMNgo THHo HMJamrozy DMatamoros SfalseLimited contribution of non-intensive chicken farming to ESBL-producing Escherichia coli colonization in humans in Vietnam: an epidemiological and genomic analysis.<h4>Objectives</h4>To investigate the risk of colonization with ESBL-producing Escherichia coli (ESBL-Ec) in humans in Vietnam associated with non-intensive chicken farming.<h4>Methods</h4>Faecal samples from 204 randomly selected farmers and their chickens, and from 306 age- and sex-matched community-based individuals who did not raise poultry were collected. Antimicrobial usage in chickens and humans was assessed by medicine cabinet surveys. WGS was employed to obtain a high-resolution genomic comparison between ESBL-Ec isolated from humans and chickens.<h4>Results</h4>The adjusted prevalence of ESBL-Ec colonization was 20.0% (95% CI 10.8%-29.1%) and 35.2% (95% CI 30.4%-40.1%) in chicken farms and humans in Vietnam, respectively. Colonization with ESBL-Ec in humans was associated with an2019-01-01T00:00:00Z2019 Mar2025-04-25T23:19:57.517Z2019-08-04T07:32:15ZS-EPMC63768493062919710.1093/jac/dky506