biostudies-literatureUnderwood JNational Institute for Health Research (NIHR)Wellcome Trust787-790https://www.ebi.ac.uk/biostudies/studies/S-EPMC6376853biostudies-literatureUnknown74(3)<h4>Background</h4>Drug-related adverse events (AEs) are reported to be common amongst patients receiving outpatient parenteral antimicrobial therapy (OPAT). However, comparative data regarding intravenous (iv) catheter-related AEs are lacking.<h4>Objectives</h4>To compare drug- and iv catheter-related AEs from a large UK OPAT centre.<h4>Patients and methods</h4>We reviewed 544 OPAT episodes [median (IQR) age: 57 (39-71) years, 60% male, 13% with diabetes] with a median (IQR) duration of 7 (2-18) days. Clinically significant drug- and iv catheter-related AEs were calculated as a percentage of OPAT episodes with an AE and also as AEs per 1000 iv drug/catheter days.<h4>Results</h4>Drug-related AEs complicated 13 (2.4%) OPAT episodes at 1.7 (95% CI 0.9-2.9) per 1000 drug days. Catheter-relateThe Journal of antimicrobial chemotherapyIntravenous catheter-related adverse events exceed drug-related adverse events in outpatient parenteral antimicrobial therapy.PMC6376853CL-2016-20-001WT102807CL-2016-18-011WT101766Pollara GCollins SUnderwood JLogan SMarks MfalseIntravenous catheter-related adverse events exceed drug-related adverse events in outpatient parenteral antimicrobial therapy.<h4>Background</h4>Drug-related adverse events (AEs) are reported to be common amongst patients receiving outpatient parenteral antimicrobial therapy (OPAT). However, comparative data regarding intravenous (iv) catheter-related AEs are lacking.<h4>Objectives</h4>To compare drug- and iv catheter-related AEs from a large UK OPAT centre.<h4>Patients and methods</h4>We reviewed 544 OPAT episodes [median (IQR) age: 57 (39-71) years, 60% male, 13% with diabetes] with a median (IQR) duration of 7 (2-18) days. Clinically significant drug- and iv catheter-related AEs were calculated as a percentage of OPAT episodes with an AE and also as AEs per 1000 iv drug/catheter days.<h4>Results</h4>Drug-related AEs complicated 13 (2.4%) OPAT episodes at 1.7 (95% CI 0.9-2.9) per 1000 drug days. Catheter-relate2019-01-01T00:00:00Z2019 Mar2026-07-09T13:22:11.197Z2019-08-04T07:32:15ZS-EPMC63768533046223710.1093/jac/dky474