biostudies-literatureAnand SNorwegian Research CouncilNICHD NIH HHSNIDDK NIH HHSe024426https://www.ebi.ac.uk/biostudies/studies/S-EPMC6377540biostudies-literatureUnknown9(2)<h4>Introduction</h4>Vitamin B12 deficiency is highly prevalent in pregnant Indian women. Neuropsychological tests have shown an association between low maternal vitamin B12 status and poorer cognitive performances in the offspring, although findings from these studies have been inconsistent. Vitamin B12 has an important role in the formation of myelin which is important for the transmission speed of neural impulses and myelination in the central nervous system has been linked to cognition. Assessing neurophysiological measures using event-related potentials (ERPs) in children may provide additional information on the effect of maternal vitamin B12 supplementation on offspring brain function. The study examines the effects of oral vitamin B12 daily supplements (50 µg) to pregnant Indian woBMJ openEffects of maternal B12 supplementation on neurophysiological outcomes in children: a study protocol for an extended follow-up from a placebo randomised control trial in Bangalore, India.PMC6377540K24 DK104676P30 DK040561R03 HD054323Srinivasan KThomas SStrand TAAnand SJayachandra MThomas TKurpad AVDuggan CPfalseEffects of maternal B12 supplementation on neurophysiological outcomes in children: a study protocol for an extended follow-up from a placebo randomised control trial in Bangalore, India.<h4>Introduction</h4>Vitamin B12 deficiency is highly prevalent in pregnant Indian women. Neuropsychological tests have shown an association between low maternal vitamin B12 status and poorer cognitive performances in the offspring, although findings from these studies have been inconsistent. Vitamin B12 has an important role in the formation of myelin which is important for the transmission speed of neural impulses and myelination in the central nervous system has been linked to cognition. Assessing neurophysiological measures using event-related potentials (ERPs) in children may provide additional information on the effect of maternal vitamin B12 supplementation on offspring brain function. The study examines the effects of oral vitamin B12 daily supplements (50 µg) to pregnant Indian wo2019-01-01T00:00:00Z2019 Feb2026-05-07T04:18:49.756Z2026-04-07T22:28:13.894ZS-EPMC63775403078290410.1136/bmjopen-2018-024426