{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Baudry A"],"funding":["Agence Nationale de la Recherche"],"pagination":["91"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6379337"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Serotonin transporter, SERT (<i>SLC64A</i> for solute carrier family 6, member A4), is a twelve transmembrane domain (TMDs) protein that assumes the uptake of serotonin (5-HT) through dissipation of the Na<sup>+</sup> gradient established by the electrogenic pump Na/K ATPase. Abnormalities in 5-HT level and signaling have been associated with various disorders of the central nervous system (CNS) such as depression, obsessive-compulsive disorder, anxiety disorders, and autism spectrum disorder. Since the 50s, SERT has raised a lot of interest as being the target of a class of antidepressants, the Serotonin Selective Reuptake Inhibitors (SSRIs), used in clinics to combat depressive states. Because of the refractoriness of two-third of patients to SSRI treatment, a better understanding of the"],"journal":["Frontiers in neuroscience"],"pubmed_title":["Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response."],"pmcid":["PMC6379337"],"funding_grant_id":["ANR-13-SAMA-0001"],"pubmed_authors":["Baudry A","Pietri M","Launay JM","Kellermann O","Schneider B"],"additional_accession":[]},"is_claimable":false,"name":"Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response.","description":"Serotonin transporter, SERT (<i>SLC64A</i> for solute carrier family 6, member A4), is a twelve transmembrane domain (TMDs) protein that assumes the uptake of serotonin (5-HT) through dissipation of the Na<sup>+</sup> gradient established by the electrogenic pump Na/K ATPase. Abnormalities in 5-HT level and signaling have been associated with various disorders of the central nervous system (CNS) such as depression, obsessive-compulsive disorder, anxiety disorders, and autism spectrum disorder. Since the 50s, SERT has raised a lot of interest as being the target of a class of antidepressants, the Serotonin Selective Reuptake Inhibitors (SSRIs), used in clinics to combat depressive states. Because of the refractoriness of two-third of patients to SSRI treatment, a better understanding of the","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-18T16:32:06.116Z","creation":"2019-06-06T20:52:44Z"},"accession":"S-EPMC6379337","cross_references":{"pubmed":["30809118"],"doi":["10.3389/fnins.2019.00091"]}}