biostudies-literatureBaudry AAgence Nationale de la Recherche91https://www.ebi.ac.uk/biostudies/studies/S-EPMC6379337biostudies-literatureUnknown13Serotonin transporter, SERT (<i>SLC64A</i> for solute carrier family 6, member A4), is a twelve transmembrane domain (TMDs) protein that assumes the uptake of serotonin (5-HT) through dissipation of the Na⁺ gradient established by the electrogenic pump Na/K ATPase. Abnormalities in 5-HT level and signaling have been associated with various disorders of the central nervous system (CNS) such as depression, obsessive-compulsive disorder, anxiety disorders, and autism spectrum disorder. Since the 50s, SERT has raised a lot of interest as being the target of a class of antidepressants, the Serotonin Selective Reuptake Inhibitors (SSRIs), used in clinics to combat depressive states. Because of the refractoriness of two-third of patients to SSRI treatment, a better understanding of theFrontiers in neuroscienceMultifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response.PMC6379337ANR-13-SAMA-0001Baudry APietri MLaunay JMKellermann OSchneider BfalseMultifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response.Serotonin transporter, SERT (<i>SLC64A</i> for solute carrier family 6, member A4), is a twelve transmembrane domain (TMDs) protein that assumes the uptake of serotonin (5-HT) through dissipation of the Na⁺ gradient established by the electrogenic pump Na/K ATPase. Abnormalities in 5-HT level and signaling have been associated with various disorders of the central nervous system (CNS) such as depression, obsessive-compulsive disorder, anxiety disorders, and autism spectrum disorder. Since the 50s, SERT has raised a lot of interest as being the target of a class of antidepressants, the Serotonin Selective Reuptake Inhibitors (SSRIs), used in clinics to combat depressive states. Because of the refractoriness of two-third of patients to SSRI treatment, a better understanding of the2019-01-01T00:00:00Z20192025-04-18T16:32:06.116Z2019-06-06T20:52:44ZS-EPMC63793373080911810.3389/fnins.2019.00091