{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Macrin D"],"funding":["U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","U.S. Department of Health & Human Services | National Institutes of Health","NIDDK NIH HHS","Howard Hughes Medical Institute","NHLBI NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health (NIH)","University of Washington's Proteomics Resource (UWPR95794). CoMotion Innovation Fund.","NIGMS NIH HHS"],"pagination":["2195"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6379364"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Tissue resident adult stem cells are known to participate in tissue regeneration and repair that follows cell turnover, or injury. It has been well established that aging impedes the regeneration capabilities at the cellular level, but it is not clear if the different onset of stem cell aging between individuals can be predicted or prevented at an earlier stage. Here we studied the dental pulp stem cells (DPSCs), a population of adult stem cells that is known to participate in the repair of an injured tooth, and its properties can be affected by aging. The dental pulp from third molars of a diverse patient group were surgically extracted, generating cells that had a high percentage of mesenchymal stem cell markers CD29, CD44, CD146 and Stro1 and had the ability to differentiate into osteo/"],"journal":["Scientific reports"],"pubmed_title":["Metabolism as an early predictor of DPSCs aging."],"pmcid":["PMC6379364"],"funding_grant_id":["R01GM097372","R01GM97372-03S1","U01HL099997","P01 GM081619","1P01GM081619","P30 DK017047","UO1HL099993","U01 HL099997","R01 GM097372","U01 HL099993","R01 GM083867","R01GM083867"],"pubmed_authors":["Ruohola-Baker H","Detraux D","Devi A","Robitaille AM","Madan A","Alghadeer A","Zhao YT","Macrin D","Mathieu J","Moon RT","Hussein AM","Miklas JW","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Metabolism as an early predictor of DPSCs aging.","description":"Tissue resident adult stem cells are known to participate in tissue regeneration and repair that follows cell turnover, or injury. It has been well established that aging impedes the regeneration capabilities at the cellular level, but it is not clear if the different onset of stem cell aging between individuals can be predicted or prevented at an earlier stage. Here we studied the dental pulp stem cells (DPSCs), a population of adult stem cells that is known to participate in the repair of an injured tooth, and its properties can be affected by aging. The dental pulp from third molars of a diverse patient group were surgically extracted, generating cells that had a high percentage of mesenchymal stem cell markers CD29, CD44, CD146 and Stro1 and had the ability to differentiate into osteo/","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2026-05-01T10:31:01.329Z","creation":"2019-06-06T20:52:44Z"},"accession":"S-EPMC6379364","cross_references":{"pubmed":["30778087"],"doi":["10.1038/s41598-018-37489-4"]}}