{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kirk EA"],"funding":["Alexander Graham Bell Scholarship","Natural Sciences and Engineering Council of Canada Discovery Grant"],"pagination":["10-11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6383552"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["51(1)"],"pubmed_abstract":["The ATP2A2 gene encodes the SERCA protein required for active calcium reuptake to the sarcoplasmic reticulum in cardiac and slow-twitch skeletal muscle. The ATP2A2 rs3026468 variant has been associated with voluntary strength phenotypes in humans but requires further validation. Here we investigated a homogenous cohort of 80 young, healthy, active Caucasian males who were assessed for maximal isometric strength, voluntary activation, stimulated contractile properties, and muscle potentiation in the quadriceps. A dynamometer was used to record knee extensions, and electrical stimulation was applied to the thigh to elicit a twitch response. DNA was isolated from cheek swabs, and the rs3026468 genotypes were assessed by TaqMan primer quantitative PCR. The results show no association between A"],"journal":["Physiological genomics"],"pubmed_title":["ATP2A2 rs3026468 does not associate with quadriceps contractile properties and acute muscle potentiation in humans."],"pmcid":["PMC6383552"],"funding_grant_id":["180970","CGSD3 - 519372 - 2018"],"pubmed_authors":["Singh SM","Kirk EA","Rice CL"],"additional_accession":[]},"is_claimable":false,"name":"ATP2A2 rs3026468 does not associate with quadriceps contractile properties and acute muscle potentiation in humans.","description":"The ATP2A2 gene encodes the SERCA protein required for active calcium reuptake to the sarcoplasmic reticulum in cardiac and slow-twitch skeletal muscle. The ATP2A2 rs3026468 variant has been associated with voluntary strength phenotypes in humans but requires further validation. Here we investigated a homogenous cohort of 80 young, healthy, active Caucasian males who were assessed for maximal isometric strength, voluntary activation, stimulated contractile properties, and muscle potentiation in the quadriceps. A dynamometer was used to record knee extensions, and electrical stimulation was applied to the thigh to elicit a twitch response. DNA was isolated from cheek swabs, and the rs3026468 genotypes were assessed by TaqMan primer quantitative PCR. The results show no association between A","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2025-04-05T15:17:34.041Z","creation":"2019-06-06T20:53:25Z"},"accession":"S-EPMC6383552","cross_references":{"pubmed":["30526312"],"doi":["10.1152/physiolgenomics.00085.2018"]}}