{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu L"],"funding":["Natural Science Foundation for Young Scientists and the Science & Technology Planning Project of Gansu Province","Natural Science Foundation for Young Scientists and the Science & Technology Planning Project of Gansu Province","Chinese foundation for hepatitis prevention and control——TianQing liver disease research fund subject","National Natural Science Foundation of China","Key Technology Research and Development Program of the Sichuan Province","Chinese foundation for hepatitis prevention and control--TianQing liver disease research fund subject"],"pagination":["98"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6385474"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(1)"],"pubmed_abstract":["Background
Circular RNAs (circRNAs) play important roles in tumourigenesis and tumour progression. However, the expression profiles and functions of circRNAs in hepatocellular carcinoma (HCC) are largely unclear.Methods
The expression profiles of circRNAs in HCC were identified through microarray analysis and were validated through quantitative reverse transcription polymerase chain reaction (qRT-PCR). Survival curves were plotted using the Kaplan-Meier method and compared using the log-rank test. The circular structure of candidate circRNA was confirmed through Sanger sequencing, divergent primer PCR, and RNase R treatments. Proliferation of HCC cells was evaluated in vitro and in vivo. The microRNA (miRNA) sponge mechanism of circRNAs was demonstrated using dual-luciferas"],"journal":["Journal of experimental & clinical cancer research : CR"],"pubmed_title":["CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth."],"pmcid":["PMC6385474"],"funding_grant_id":["TQGB20190202","18JR3RA058","2015SZ0131","71673193","2017FZ0082","19ZDYF1740"],"pubmed_authors":["Xu L","Wang P","Zheng X","Xu M","Feng X","Zhang Y","Hao X","Zhang M","Li L","Ren S"],"additional_accession":[]},"is_claimable":false,"name":"CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth.","description":"Background
Circular RNAs (circRNAs) play important roles in tumourigenesis and tumour progression. However, the expression profiles and functions of circRNAs in hepatocellular carcinoma (HCC) are largely unclear.Methods
The expression profiles of circRNAs in HCC were identified through microarray analysis and were validated through quantitative reverse transcription polymerase chain reaction (qRT-PCR). Survival curves were plotted using the Kaplan-Meier method and compared using the log-rank test. The circular structure of candidate circRNA was confirmed through Sanger sequencing, divergent primer PCR, and RNase R treatments. Proliferation of HCC cells was evaluated in vitro and in vivo. The microRNA (miRNA) sponge mechanism of circRNAs was demonstrated using dual-luciferas","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2026-07-16T19:14:32.852Z","creation":"2019-08-03T07:21:13Z"},"accession":"S-EPMC6385474","cross_references":{"pubmed":["30795787"],"doi":["10.1186/s13046-019-1041-2"]}}