{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Beck JC"],"funding":["Division of Chemistry","Research Corporation for Science Advancement","National Institute of General Medical Sciences","NIGMS NIH HHS","Division of Graduate Education"],"pagination":["2315-2319"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6385545"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(8)"],"pubmed_abstract":["A modular synthesis of enantioenriched polyfunctionalized cyclobutanes was developed that features an 8-aminoquinolinamide directed C-H arylation reaction. The C-H arylation products were derivatized through subsequent decarboxylative coupling processes. This synthetic strategy enabled a 9-step enantioselective total synthesis of the antiproliferative meroterpenoid (+)-rumphellaone A."],"journal":["Chemical science"],"pubmed_title":["A modular approach to prepare enantioenriched cyclobutanes: synthesis of (+)-rumphellaone A."],"pmcid":["PMC6385545"],"funding_grant_id":["5T32GM007616-39","DGE-1144469","R35 GM118191","CAREER-1057143","R35GM118191-01","20845","T32 GM007616"],"pubmed_authors":["Chapman LM","Reisman SE","Lacker CR","Beck JC"],"additional_accession":[]},"is_claimable":false,"name":"A modular approach to prepare enantioenriched cyclobutanes: synthesis of (+)-rumphellaone A.","description":"A modular synthesis of enantioenriched polyfunctionalized cyclobutanes was developed that features an 8-aminoquinolinamide directed C-H arylation reaction. The C-H arylation products were derivatized through subsequent decarboxylative coupling processes. This synthetic strategy enabled a 9-step enantioselective total synthesis of the antiproliferative meroterpenoid (+)-rumphellaone A.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2026-05-07T11:22:11.188Z","creation":"2019-08-04T07:14:37Z"},"accession":"S-EPMC6385545","cross_references":{"pubmed":["30881657"],"doi":["10.1039/c8sc05444d"]}}