{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["39(2)"],"submitter":["Chen W"],"pubmed_abstract":["Nephrolithiasis is one of the world's major public health burdens with a high incidence and a risk of persistent renal dysfunction. Fu-Fang-Jin-Qian-Chao granules (FFJQC), a traditional Chinese herb formula, is commonly used in treatment of nephrolithiasis. However, the therapeutic mechanism of FFJQC on kidney stone has still been a mystery. The objective of the present study is to explore the therapeutic mechanism of FFJQC on kidney injury and identify unique metabolomics patterns using a mouse model of kidney stone induced by a calcium oxalate (CaOx) deposition. Von Kossa staining and immuno-histopathological staining of osteopontin (OPN), cluster of differentiation 44 (CD44) and calbindin-D28k were conducted on renal sections. Biochemical analysis was performed on serum, urine, and kidn"],"journal":["Bioscience reports"],"pagination":["BSR20181833"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6386768"],"repository":["biostudies-literature"],"pubmed_title":["Metabolomic analysis reveals a protective effect of Fu-Fang-Jin-Qian-Chao herbal granules on oxalate-induced kidney injury."],"pmcid":["PMC6386768"],"pubmed_authors":["Gao SY","Ma JH","Hou JB","Dong X","Guo ZY","Chen W","Ding JR","Peng ZJ","Lin QS","Lu JR","Liu WR"],"additional_accession":[]},"is_claimable":false,"name":"Metabolomic analysis reveals a protective effect of Fu-Fang-Jin-Qian-Chao herbal granules on oxalate-induced kidney injury.","description":"Nephrolithiasis is one of the world's major public health burdens with a high incidence and a risk of persistent renal dysfunction. Fu-Fang-Jin-Qian-Chao granules (FFJQC), a traditional Chinese herb formula, is commonly used in treatment of nephrolithiasis. However, the therapeutic mechanism of FFJQC on kidney stone has still been a mystery. The objective of the present study is to explore the therapeutic mechanism of FFJQC on kidney injury and identify unique metabolomics patterns using a mouse model of kidney stone induced by a calcium oxalate (CaOx) deposition. Von Kossa staining and immuno-histopathological staining of osteopontin (OPN), cluster of differentiation 44 (CD44) and calbindin-D28k were conducted on renal sections. Biochemical analysis was performed on serum, urine, and kidn","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2026-07-16T21:38:36.2Z","creation":"2026-07-10T03:16:29.524Z"},"accession":"S-EPMC6386768","cross_references":{"pubmed":["30737304"],"doi":["10.1042/BSR20181833"]}}