biostudies-literatureUnknown8Joshi CBackground:Punica granatum extracts have been prescribed in traditional medicine for management of a variety of disease conditions including microbial infections. Generation of scientific evidence for validation of P. granatum peel extract's anti-pathogenic efficacy is required. Methods: Hydroalcoholic extract of P. granatum peel (PGPE), prepared by microwave assisted extraction method was evaluated for its quorum-modulatory potential against two different human-pathogenic bacteria viz. Chromobacterium violaceum and Pseudomonas aeruginosa. Results: This extract was able to modulate in vitro production of quorum sensing-regulated pigments in both these test bacteria at ≥5 μg/ml. Virulence traits of P. aeruginosa like haemF1000Research70https://www.ebi.ac.uk/biostudies/studies/S-EPMC6392158biostudies-literatureAnti-infective potential of hydroalcoholic extract of Punica granatum peel against gram-negative bacterial pathogens.PMC6392158Patel PKothari VJoshi CfalseAnti-infective potential of hydroalcoholic extract of Punica granatum peel against gram-negative bacterial pathogens.Background:Punica granatum extracts have been prescribed in traditional medicine for management of a variety of disease conditions including microbial infections. Generation of scientific evidence for validation of P. granatum peel extract's anti-pathogenic efficacy is required. Methods: Hydroalcoholic extract of P. granatum peel (PGPE), prepared by microwave assisted extraction method was evaluated for its quorum-modulatory potential against two different human-pathogenic bacteria viz. Chromobacterium violaceum and Pseudomonas aeruginosa. Results: This extract was able to modulate in vitro production of quorum sensing-regulated pigments in both these test bacteria at ≥5 μg/ml. Virulence traits of P. aeruginosa like haem2019-01-01T00:00:00Z20192025-04-05T12:45:04.785Z2019-06-06T22:46:01ZS-EPMC63921583082844110.12688/f1000research.17430.2