{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Grilz-Seger G"],"funding":["Österreichische Forschungsförderungsgesellschaft","Bundesministerium für Nachhaltigkeit und Tourismus (AT)","Bundesministerium für Nachhaltigkeit und Tourismus"],"pagination":["174"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6402180"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["Background
The sample ascertainment bias due to complex population structures remains a major challenge in genome-wide investigations of complex traits. In this study we derived the high-resolution population structure and levels of autozygosity of 377 Lipizzan horses originating from five different European stud farms utilizing the SNP genotype information of the high density 700 k Affymetrix Axiom™ Equine genotyping array. Scanning the genome for overlapping runs of homozygosity (ROH) shared by more than 50% of horses, we identified homozygous regions (ROH islands) in order to investigate the gene content of those candidate regions by gene ontology and enrichment analyses.Results
The high-resolution population network approach revealed well-defined substructures according"],"journal":["BMC genomics"],"pubmed_title":["High-resolution population structure and runs of homozygosity reveal the genetic architecture of complex traits in the Lipizzan horse."],"pmcid":["PMC6402180"],"funding_grant_id":["101332","843464"],"pubmed_authors":["Neuditschko M","Dobretsberger M","Brem G","Druml T","Grilz-Seger G","Horna M"],"additional_accession":[]},"is_claimable":false,"name":"High-resolution population structure and runs of homozygosity reveal the genetic architecture of complex traits in the Lipizzan horse.","description":"Background
The sample ascertainment bias due to complex population structures remains a major challenge in genome-wide investigations of complex traits. In this study we derived the high-resolution population structure and levels of autozygosity of 377 Lipizzan horses originating from five different European stud farms utilizing the SNP genotype information of the high density 700 k Affymetrix Axiom™ Equine genotyping array. Scanning the genome for overlapping runs of homozygosity (ROH) shared by more than 50% of horses, we identified homozygous regions (ROH islands) in order to investigate the gene content of those candidate regions by gene ontology and enrichment analyses.Results
The high-resolution population network approach revealed well-defined substructures according","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2026-05-03T01:19:18.182Z","creation":"2025-05-29T19:54:19.661Z"},"accession":"S-EPMC6402180","cross_references":{"pubmed":["30836959"],"doi":["10.1186/s12864-019-5564-x"]}}