{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Perruchot MH"],"funding":["Animal Physiology &amp; Livestock System Department of the French National Institute for Agricultural Research (INRA) and CCPA group"],"pubmed_abstract":["<h4>Background</h4>High-yielding dairy cows are prone to oxidative stress due to the high metabolic needs of homeostasis and milk production. Oxidative stress and inflammation are tightly linked; therefore, anti-inflammatory and/or natural antioxidant compounds may help improve mammary cell health. Baicalin, one of the major flavonoids in <i>Scutellaria baicalensis</i>, has natural antioxidant and anti-inflammatory properties in various cell types, but its effects on bovine mammary epithelial cells (BMECs) have not been investigated.<h4>Methods</h4>Explants from bovine mammary glands were collected by biopsy at the peak of lactation (approximately 60 days after the start of lactation) (<i>n</i> = three animals) to isolate BMECs corresponding to mature secretory cells. Cell viability, apopt"],"journal":["PeerJ"],"pagination":["e6565"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6407502"],"repository":["biostudies-literature"],"pubmed_title":["Effect of the flavonoid baicalin on the proliferative capacity of bovine mammary cells and their ability to regulate oxidative stress."],"pmcid":["PMC6407502"],"pubmed_authors":["Dessauge F","Perruchot MH","Robert F","Quesnel H","Gondret F","Dupuis E"],"additional_accession":[]},"is_claimable":false,"name":"Effect of the flavonoid baicalin on the proliferative capacity of bovine mammary cells and their ability to regulate oxidative stress.","description":"<h4>Background</h4>High-yielding dairy cows are prone to oxidative stress due to the high metabolic needs of homeostasis and milk production. Oxidative stress and inflammation are tightly linked; therefore, anti-inflammatory and/or natural antioxidant compounds may help improve mammary cell health. Baicalin, one of the major flavonoids in <i>Scutellaria baicalensis</i>, has natural antioxidant and anti-inflammatory properties in various cell types, but its effects on bovine mammary epithelial cells (BMECs) have not been investigated.<h4>Methods</h4>Explants from bovine mammary glands were collected by biopsy at the peak of lactation (approximately 60 days after the start of lactation) (<i>n</i> = three animals) to isolate BMECs corresponding to mature secretory cells. Cell viability, apopt","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-04-07T14:21:49.755Z","creation":"2019-06-06T20:58:12Z"},"accession":"S-EPMC6407502","cross_references":{"pubmed":["30863682"],"doi":["10.7717/peerj.6565"]}}