biostudies-literatureUnknown7Perruchot MHAnimal Physiology &amp; Livestock System Department of the French National Institute for Agricultural Research (INRA) and CCPA group<h4>Background</h4>High-yielding dairy cows are prone to oxidative stress due to the high metabolic needs of homeostasis and milk production. Oxidative stress and inflammation are tightly linked; therefore, anti-inflammatory and/or natural antioxidant compounds may help improve mammary cell health. Baicalin, one of the major flavonoids in <i>Scutellaria baicalensis</i>, has natural antioxidant and anti-inflammatory properties in various cell types, but its effects on bovine mammary epithelial cells (BMECs) have not been investigated.<h4>Methods</h4>Explants from bovine mammary glands were collected by biopsy at the peak of lactation (approximately 60 days after the start of lactation) (<i>n</i> = three animals) to isolate BMECs corresponding to mature secretory cells. Cell viability, apoptPeerJe6565https://www.ebi.ac.uk/biostudies/studies/S-EPMC6407502biostudies-literatureEffect of the flavonoid baicalin on the proliferative capacity of bovine mammary cells and their ability to regulate oxidative stress.PMC6407502Dessauge FPerruchot MHRobert FQuesnel HGondret FDupuis EfalseEffect of the flavonoid baicalin on the proliferative capacity of bovine mammary cells and their ability to regulate oxidative stress.<h4>Background</h4>High-yielding dairy cows are prone to oxidative stress due to the high metabolic needs of homeostasis and milk production. Oxidative stress and inflammation are tightly linked; therefore, anti-inflammatory and/or natural antioxidant compounds may help improve mammary cell health. Baicalin, one of the major flavonoids in <i>Scutellaria baicalensis</i>, has natural antioxidant and anti-inflammatory properties in various cell types, but its effects on bovine mammary epithelial cells (BMECs) have not been investigated.<h4>Methods</h4>Explants from bovine mammary glands were collected by biopsy at the peak of lactation (approximately 60 days after the start of lactation) (<i>n</i> = three animals) to isolate BMECs corresponding to mature secretory cells. Cell viability, apopt2019-01-01T00:00:00Z20192026-04-07T14:21:49.755Z2019-06-06T20:58:12ZS-EPMC64075023086368210.7717/peerj.6565