{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu K"],"funding":["National Natural Science Foundation of China"],"pagination":["243"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6411878"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(3)"],"pubmed_abstract":["p53 is an essential tumor suppressor, whose activity is finely tuned by the posttranslational modifications. Previous research has reported that β-hydroxybutyrate (BHB) induces β-hydroxybutyrylation (Kbhb), which is a novel histone posttranslational modification. Here we report that p53 is modified by kbhb and that this modification occurs at lysines 120, 319, and 370 of p53. We demonstrate that the level of p53 kbhb is dramatically increased in cultured cells treated with BHB and in thymus tissues of fasted mice, and that CBP catalyze p53 kbhb. We show that p53 kbhb results in lower levels of p53 acetylation and reduced expression of the p53 downstream genes p21 and PUMA, as well as reduced cell growth arrest and apoptosis in cultured cells under p53-activating conditions. Similar results"],"journal":["Cell death & disease"],"pubmed_title":["p53 β-hydroxybutyrylation attenuates p53 activity."],"pmcid":["PMC6411878"],"funding_grant_id":["85141044"],"pubmed_authors":["Liu K","Tian F","Li F","Gu W","Zhao W","Tong T","Geng M","Zhao Y","You K","Sun Q","Li T","Han H","Lin N","Mao Z"],"additional_accession":[]},"is_claimable":false,"name":"p53 β-hydroxybutyrylation attenuates p53 activity.","description":"p53 is an essential tumor suppressor, whose activity is finely tuned by the posttranslational modifications. Previous research has reported that β-hydroxybutyrate (BHB) induces β-hydroxybutyrylation (Kbhb), which is a novel histone posttranslational modification. Here we report that p53 is modified by kbhb and that this modification occurs at lysines 120, 319, and 370 of p53. We demonstrate that the level of p53 kbhb is dramatically increased in cultured cells treated with BHB and in thymus tissues of fasted mice, and that CBP catalyze p53 kbhb. We show that p53 kbhb results in lower levels of p53 acetylation and reduced expression of the p53 downstream genes p21 and PUMA, as well as reduced cell growth arrest and apoptosis in cultured cells under p53-activating conditions. Similar results","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Mar","modification":"2026-07-10T03:17:01.393Z","creation":"2019-08-04T08:23:30Z"},"accession":"S-EPMC6411878","cross_references":{"pubmed":["30858356"],"doi":["10.1038/s41419-019-1463-y"]}}