biostudies-literatureFaggi LMinistero della SaluteUniversità degli Studi di BresciaFP7-Marie Curie- ITN 2013E345https://www.ebi.ac.uk/biostudies/studies/S-EPMC6412333biostudies-literatureUnknown11(2)Bioactive components, due in part to their epigenetic properties, are beneficial for preventing several human diseases including cerebrovascular pathologies. However, no clear demonstration supports the idea that these molecules still conserve their epigenetic effects when acting at very low concentrations reproducing the brain levels achieved after oral administration of a micronutrient supplement. In the present study, we used a cellular model of brain ischemia to investigate the neuroprotective and epigenetic activities of a commercially available micronutrient mixture (polyphenol-enriched micronutrient mixture, PMM) enriched in polyphenols ((-)-epigallocatechin-3-gallate, quercetin, resveratrol), α-lipoic acid, vitamins, amino acids and other micronutrients. Mimicking the suggested dieNutrientsA Polyphenol-Enriched Supplement Exerts Potent Epigenetic-Protective Activity in a Cell-Based Model of Brain Ischemia.PMC6412333BIOMANE 2016-Health & Wealth projectRF-2010-2315142607962BIOMANE 2016-Health & Wealth projectBenarese MPizzi MPorrini VLanzillotta ATsoukalas DParrella EMota MFaggi LfalseA Polyphenol-Enriched Supplement Exerts Potent Epigenetic-Protective Activity in a Cell-Based Model of Brain Ischemia.Bioactive components, due in part to their epigenetic properties, are beneficial for preventing several human diseases including cerebrovascular pathologies. However, no clear demonstration supports the idea that these molecules still conserve their epigenetic effects when acting at very low concentrations reproducing the brain levels achieved after oral administration of a micronutrient supplement. In the present study, we used a cellular model of brain ischemia to investigate the neuroprotective and epigenetic activities of a commercially available micronutrient mixture (polyphenol-enriched micronutrient mixture, PMM) enriched in polyphenols ((-)-epigallocatechin-3-gallate, quercetin, resveratrol), α-lipoic acid, vitamins, amino acids and other micronutrients. Mimicking the suggested die2019-01-01T00:00:00Z2019 Feb2026-07-17T00:10:54.581Z2019-08-04T07:41:04ZS-EPMC64123333073631310.3390/nu11020345