{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(4)"],"submitter":["Xu Y"],"pubmed_abstract":["Artemisia integrifolia L (Compositae) is a medicinal and edible plant. To investigate its antihyperlipidemic effect, a crude lipophilic extract and the composing compounds were isolated and fractioned from the petroleum ether extract of aerial parts of A. integrifolia using column chromatography on silica gel. The anti-hyperlipidemia effect was studied in a rat model of acute hyperlipidemia, which was induced by triton WR-1339. A new compound, integrinol (4), together with nine known compounds, namely chamazulene (1), acetylenes (E)-2 (2), acetylenes (E)-3 (3), eugenol (5), palmitic acid (6), oleic acid (7), linoleic acid (8), linolenic acid (9) and 12,13-epoxylinolenic acid were isolated from the crude lipophilic extract of A. integrifolia. The LD50 value of the crude extract was more tha"],"journal":["Molecules (Basel, Switzerland)"],"pagination":["E725"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6412335"],"repository":["biostudies-literature"],"pubmed_title":["Antihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia."],"pmcid":["PMC6412335"],"pubmed_authors":["Wang Q","Pa B","Bao W","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Antihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia.","description":"Artemisia integrifolia L (Compositae) is a medicinal and edible plant. To investigate its antihyperlipidemic effect, a crude lipophilic extract and the composing compounds were isolated and fractioned from the petroleum ether extract of aerial parts of A. integrifolia using column chromatography on silica gel. The anti-hyperlipidemia effect was studied in a rat model of acute hyperlipidemia, which was induced by triton WR-1339. A new compound, integrinol (4), together with nine known compounds, namely chamazulene (1), acetylenes (E)-2 (2), acetylenes (E)-3 (3), eugenol (5), palmitic acid (6), oleic acid (7), linoleic acid (8), linolenic acid (9) and 12,13-epoxylinolenic acid were isolated from the crude lipophilic extract of A. integrifolia. The LD50 value of the crude extract was more tha","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2025-04-19T20:03:14.47Z","creation":"2019-06-05T15:41:47Z"},"accession":"S-EPMC6412335","cross_references":{"pubmed":["30781592"],"doi":["10.3390/molecules24040725"]}}