biostudies-literatureUnknown24(4)Xu YArtemisia integrifolia L (Compositae) is a medicinal and edible plant. To investigate its antihyperlipidemic effect, a crude lipophilic extract and the composing compounds were isolated and fractioned from the petroleum ether extract of aerial parts of A. integrifolia using column chromatography on silica gel. The anti-hyperlipidemia effect was studied in a rat model of acute hyperlipidemia, which was induced by triton WR-1339. A new compound, integrinol (4), together with nine known compounds, namely chamazulene (1), acetylenes (E)-2 (2), acetylenes (E)-3 (3), eugenol (5), palmitic acid (6), oleic acid (7), linoleic acid (8), linolenic acid (9) and 12,13-epoxylinolenic acid were isolated from the crude lipophilic extract of A. integrifolia. The LD50 value of the crude extract was more thaMolecules (Basel, Switzerland)E725https://www.ebi.ac.uk/biostudies/studies/S-EPMC6412335biostudies-literatureAntihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia.PMC6412335Wang QPa BBao WXu YfalseAntihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia.Artemisia integrifolia L (Compositae) is a medicinal and edible plant. To investigate its antihyperlipidemic effect, a crude lipophilic extract and the composing compounds were isolated and fractioned from the petroleum ether extract of aerial parts of A. integrifolia using column chromatography on silica gel. The anti-hyperlipidemia effect was studied in a rat model of acute hyperlipidemia, which was induced by triton WR-1339. A new compound, integrinol (4), together with nine known compounds, namely chamazulene (1), acetylenes (E)-2 (2), acetylenes (E)-3 (3), eugenol (5), palmitic acid (6), oleic acid (7), linoleic acid (8), linolenic acid (9) and 12,13-epoxylinolenic acid were isolated from the crude lipophilic extract of A. integrifolia. The LD50 value of the crude extract was more tha2019-01-01T00:00:00Z2019 Feb2025-04-19T20:03:14.47Z2019-06-05T15:41:47ZS-EPMC64123353078159210.3390/molecules24040725